LARP4B
La Ribonucleoprotein Domain Family Member 4B
Gene Information Card
| Symbol | LARP4B |
|---|---|
| Full Name | La Ribonucleoprotein Domain Family Member 4B |
| Gene Type | Protein-coding |
| Chromosomal Location | 10p15.3 |
| NCBI Gene ID | 23185 ncbi.nlm.nih.gov/gene/23185 |
| Ensembl ID | ENSG00000107938 |
| UniProt ID | Q92615 |
| OMIM ID | 612024 |
| HGNC ID | 15579 |
| Aliases | LARP5, KIAA0217 |
Description
LARP4B encodes a member of the La-related protein family, characterized by a La motif and an RNA recognition motif. The protein binds poly(A) RNA and is involved in mRNA translation and stability, particularly in the cytoplasm. It may play roles in cell proliferation and differentiation, with implications in cancer and neurodevelopmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression associated with poor prognosis; potential role in mRNA translation regulation | PMID: 25691885 |
| Colorectal cancer | Upregulation linked to tumor progression; may affect cell cycle | PMID: 27323850 |
| Neurodevelopmental disorders | Rare variants reported in patients with intellectual disability | ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.7 | Medium |
| Lung | 6.2 | Low |
| Liver | 4.1 | Low |
| Heart | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.8 | Embryonic kidney cell line |
| HeLa | 7.5 | Cervical cancer cell line |
| MCF7 | 6.3 | Breast cancer cell line |
| HepG2 | 5.1 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.01% | Loss of function; associated with neurodevelopmental phenotypes |
| c.567G>A (p.Glu189Lys) | Missense | 0.02% | Unknown significance; reported in cancer samples |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations have been characterized.
Dominant Negative (DN)
No dominant-negative mutations have been reported.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • poly(A) RNA binding |
| • cytoplasm | • translation |
| • mRNA stabilization |
Pathways
• mRNA surveillance pathway
• Translation regulation
Protein Summary
LARP4B is a 739-amino acid protein containing a La motif and an RNA recognition motif. It localizes predominantly to the cytoplasm, where it binds poly(A) tails of mRNAs and enhances translation efficiency. The protein interacts with poly(A)-binding protein (PABPC1) and may influence cell growth and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LARP4B Knockout HEK293 Cell Line | EDJ-KQ2059 | Human | 23185 | Details Get a Quote |
| LARP4B Knockout A-549 Cell Line | EDJ-KQ22123 | Human | 23185 | Details Get a Quote |
| LARP4B Knockout HCT 116 Cell Line | EDJ-KQ22124 | Human | 23185 | Details Get a Quote |
| LARP4B Knockout HeLa Cell Line | EDJ-KQ22125 | Human | 23185 | Details Get a Quote |
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