LARP4: La Ribonucleoprotein Domain Family Member 4
A comprehensive resource for LARP4 gene information, including genomic data, expression, mutations, and associated diseases.
Gene Information Card
| Symbol | LARP4 |
|---|---|
| Full Name | La ribonucleoprotein domain family member 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q13.12 |
| NCBI Gene ID | 113251 ncbi.nlm.nih.gov/gene/113251 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | Q71RC2 |
| OMIM ID | 612022 |
| HGNC ID | 24091 |
| Aliases | FLJ12525, La-related protein 4, LARP4 |
Description
LARP4 (La ribonucleoprotein domain family member 4) is a protein-coding gene located on chromosome 12q13.12. It encodes a member of the La-related protein family, characterized by a La motif and an RNA recognition motif (RRM). LARP4 is involved in mRNA translation and stability, binding to poly(A) tails and interacting with poly(A)-binding proteins. It plays a role in cell proliferation and may be implicated in cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | LARP4 overexpression may promote cell proliferation and migration | PMID: 25605274 |
| Colorectal cancer | LARP4 upregulation associated with poor prognosis | PMID: 29351298 |
| Hepatocellular carcinoma | LARP4 knockdown reduces tumor growth in vitro | PMID: 31065034 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Bone marrow | 10.5 | Medium |
| Brain | 6.3 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.5 | Cervical cancer cell line |
| HEK293 | 14.2 | Embryonic kidney cells |
| MCF7 | 12.0 | Breast cancer cell line |
| HepG2 | 9.8 | Liver cancer cell line |
| K562 | 7.3 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349Trp) | Missense | 0.01% | Unknown |
| c.1523G>A (p.Arg508Gln) | Missense | 0.005% | Unknown |
| c.1789_1790insA (p.Thr597AsnfsTer2) | Frameshift | 0.001% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr597AsnfsTer2) likely result in truncated protein and loss of RNA-binding function.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding (GO:0003723) | • cytoplasm (GO:0005737) |
| • regulation of translation (GO:0006417) | • cadherin binding (GO:0045296) |
Pathways
• mRNA surveillance pathway
• Translation regulation by PABP and LARP4
Protein Summary
LARP4 is a 739-amino acid protein containing an N-terminal La motif and a central RRM domain. It binds poly(A) tails and interacts with poly(A)-binding protein (PABP) to enhance mRNA translation and stability. LARP4 localizes to the cytoplasm and is involved in cell growth and proliferation. Its dysregulation is associated with several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LARP4 Knockout HEK293 Cell Line | EDJ-KQ147 | Human | 113251 | Details Get a Quote |
| LARP4B Knockout HEK293 Cell Line | EDJ-KQ2059 | Human | 23185 | Details Get a Quote |
| LARP4B Knockout A-549 Cell Line | EDJ-KQ22123 | Human | 23185 | Details Get a Quote |
| LARP4B Knockout HCT 116 Cell Line | EDJ-KQ22124 | Human | 23185 | Details Get a Quote |
| LARP4B Knockout HeLa Cell Line | EDJ-KQ22125 | Human | 23185 | Details Get a Quote |
| LARP4 Knockout A-549 Cell Line | EDJ-KQ43937 | Human | 113251 | Details Get a Quote |
| LARP4 Knockout HCT 116 Cell Line | EDJ-KQ43938 | Human | 113251 | Details Get a Quote |
| LARP4 Knockout HeLa Cell Line | EDJ-KQ43939 | Human | 113251 | Details Get a Quote |
Displaying Records 1 To 8 Of 8 Records
