LANCL2 Gene - Lanthionine Synthetase C-Like 2
A key regulator of cellular energy metabolism and immune response
Gene Information Card
| Symbol | LANCL2 |
|---|---|
| Full Name | Lanthionine Synthetase C-Like 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 7q31.1 |
| NCBI Gene ID | 55915 ncbi.nlm.nih.gov/gene/55915 |
| Ensembl ID | ENSG00000132434 |
| UniProt ID | Q9NS86 |
| OMIM ID | 612919 |
| HGNC ID | 6508 |
| Aliases | GPR69B, TPRG, LANCL2 |
Description
LANCL2 (Lanthionine Synthetase C-Like 2) encodes a member of the lanthionine synthetase C-like protein family. The protein is a membrane-associated signaling molecule that binds abscisic acid (ABA) and mediates its effects on glucose uptake, insulin sensitivity, and immune cell function. LANCL2 is involved in energy metabolism, mitochondrial function, and inflammatory responses, making it a potential therapeutic target for metabolic and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Type 2 Diabetes | LANCL2 mediates abscisic acid-stimulated glucose uptake and insulin sensitization; dysregulation contributes to insulin resistance. | PMID: 21715324, PMID: 25635060 |
| Inflammatory Bowel Disease | LANCL2 activation reduces intestinal inflammation via PPAR gamma and AMPK pathways. | PMID: 24859451, PMID: 27535987 |
| Obesity | LANCL2 expression correlates with adiposity and metabolic dysfunction; modulation improves energy balance. | PMID: 25635060 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Skeletal muscle | 8.3 | Medium |
| Liver | 6.1 | Low |
| Kidney | 10.2 | Medium |
| Brain | 4.7 | Low |
| Heart | 7.9 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.3 | Hepatocellular carcinoma cell line |
| Caco-2 | 11.8 | Colorectal adenocarcinoma cell line |
| THP-1 | 9.2 | Monocytic leukemia cell line |
| 3T3-L1 | 14.0 | Adipocyte precursor cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T | Missense | 0.01% | p.Thr34Met; potential loss of ABA binding |
| c.452A>G | Missense | 0.02% | p.Asn151Ser; unknown functional impact |
| c.788G>A | Synonymous | 0.03% | p.Arg263Arg; no amino acid change |
Mutation functional classification
Loss of Function (LOF)
c.101C>T (p.Thr34Met) may impair abscisic acid binding and downstream signaling.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • ATP binding (GO:0005524) | • cytoplasm (GO:0005737) |
| • integral component of membrane (GO:0016021) | • glucose homeostasis (GO:0042593) |
| • regulation of inflammatory response (GO:0050727) | • apoptotic process (GO:0006915) |
Pathways
• Abscisic acid signaling pathway
• AMPK signaling pathway
• PPAR signaling pathway
• Insulin signaling pathway
Protein Summary
LANCL2 is a 445-amino acid protein with a molecular weight of approximately 50 kDa. It contains a conserved lanthionine synthetase C-like domain and is localized to the plasma membrane and cytoplasm. The protein binds abscisic acid (ABA) and activates signaling cascades involving AMPK and PPAR gamma, leading to enhanced glucose uptake, mitochondrial biogenesis, and anti-inflammatory effects. LANCL2 is expressed in multiple tissues, with highest levels in adipose tissue and skeletal muscle.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LANCL2 Knockout HEK293 Cell Line | EDJ-KQ14023 | Human | 55915 | Details Get a Quote |
| LANCL2 Knockout A-549 Cell Line | EDJ-KQ43929 | Human | 55915 | Details Get a Quote |
| LANCL2 Knockout HCT 116 Cell Line | EDJ-KQ43930 | Human | 55915 | Details Get a Quote |
| LANCL2 Knockout HeLa Cell Line | EDJ-KQ43931 | Human | 55915 | Details Get a Quote |
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