LAMTOR5
Late Endosomal/Lysosomal Adaptor, MAPK and MTOR Activator 5
Gene Information Card
| Symbol | LAMTOR5 |
|---|---|
| Full Name | Late Endosomal/Lysosomal Adaptor, MAPK and MTOR Activator 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p13.3 |
| NCBI Gene ID | 57142 ncbi.nlm.nih.gov/gene/57142 |
| Ensembl ID | ENSG00000117640 |
| UniProt ID | Q9Y2Q3 |
| OMIM ID | 610889 |
| HGNC ID | 25682 |
| Aliases | HBXIP, XIP, FLJ11273 |
Description
LAMTOR5 encodes a component of the Ragulator complex, which is a pentameric complex that anchors the Rag GTPases to the lysosomal membrane and is essential for amino acid-dependent activation of mTORC1. The protein also functions as a scaffold in the MAPK signaling cascade and has been implicated in cell growth, proliferation, and survival. LAMTOR5 is also known as hepatitis B virus X-interacting protein (HBXIP) due to its interaction with the HBx protein.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | LAMTOR5 (HBXIP) interacts with HBx protein, promoting cell proliferation and inhibiting apoptosis; overexpression correlates with poor prognosis. | PMID: 15601830, PMID: 21516111 |
| Breast cancer | LAMTOR5 overexpression enhances mTORC1 signaling and cell growth; acts as an oncogene. | PMID: 23327922, PMID: 26030139 |
| Gastric cancer | Upregulation of LAMTOR5 promotes tumorigenesis via mTORC1 activation. | PMID: 27323871 |
| Colorectal cancer | LAMTOR5 overexpression linked to increased proliferation and metastasis. | PMID: 28708997 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Breast | 8.3 | Low |
| Stomach | 10.1 | Medium |
| Colon | 9.7 | Medium |
| Lung | 7.4 | Low |
| Kidney | 11.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.6 | Hepatocellular carcinoma cell line |
| MCF7 | 9.8 | Breast cancer cell line |
| AGS | 11.4 | Gastric cancer cell line |
| HCT116 | 10.2 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Potential loss of start codon; likely loss of function |
| c.214C>T (p.Arg72Trp) | Missense | <0.1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in LAMTOR5.
Gain of Function (GOF)
Overexpression of wild-type LAMTOR5 is associated with oncogenic gain-of-function in various cancers.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activator activity | • protein binding |
| • lysosomal membrane | • mTORC1 signaling |
| • MAPK cascade | • cell proliferation |
| • negative regulation of apoptotic process |
Pathways
• mTORC1 signaling (Ragulator complex)
• MAPK signaling (scaffold)
• Amino acid sensing
Protein Summary
LAMTOR5 is a 91-amino acid protein that localizes to the lysosomal membrane as part of the Ragulator complex. It is essential for the recruitment and activation of mTORC1 in response to amino acids. Additionally, it serves as a scaffold for the MAPK pathway, facilitating signal transduction. Overexpression of LAMTOR5 is oncogenic in several cancers, and it interacts with the hepatitis B virus X protein to promote hepatocellular carcinoma.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LAMTOR5 Knockout HEK293 Cell Line | EDJ-KQ1149 | Human | 10542 | Details Get a Quote |
| LAMTOR5 Knockout A-549 Cell Line | EDJ-KQ19031 | Human | 10542 | Details Get a Quote |
| LAMTOR5 Knockout HCT 116 Cell Line | EDJ-KQ20375 | Human | 10542 | Details Get a Quote |
| LAMTOR5 Knockout HeLa Cell Line | EDJ-KQ20376 | Human | 10542 | Details Get a Quote |
| Lamtor5 Knockout 4T1 Cell Line | EDJ-KZ322 | Mouse | 68576 | Details Get a Quote |
| LAMTOR5 Knockout MDA-MB-231 Cell Line | EDJ-KZ323 | Human | 10542 | Details Get a Quote |
Displaying Records 1 To 6 Of 6 Records
