KRTAP10-11
Keratin Associated Protein 10-11
Gene Information Card
| Symbol | KRTAP10-11 |
|---|---|
| Full Name | Keratin Associated Protein 10-11 |
| Gene Type | Protein coding |
| Chromosomal Location | 21q22.3 |
| NCBI Gene ID | 100287596 ncbi.nlm.nih.gov/gene/100287596 |
| Ensembl ID | ENSG00000221869 |
| UniProt ID | P0C7P2 |
| OMIM ID | 616258 |
| HGNC ID | 33807 |
| Aliases | KRTAP10.11, KAP10.11 |
Description
KRTAP10-11 (Keratin Associated Protein 10-11) is a protein coding gene located on chromosome 21q22.3. It encodes a member of the high-sulfur keratin-associated protein (KAP) family, which are structural components of hair and nail matrix. These proteins crosslink with keratin intermediate filaments to provide strength and rigidity to hair shafts.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association reported | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 0.0 | Not detected |
| Hair follicle | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line expression data available | N/A | No data in GTEx or related sources |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The KRTAP10-11 protein is a high-sulfur keratin-associated protein (KAP) that contributes to the structural integrity of hair and nails. It contains a cysteine-rich domain that facilitates disulfide bonding with keratin intermediate filaments, enhancing mechanical strength. No functional studies or disease associations are currently documented.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KRTAP10-11 Knockout HEK293 Cell Line | EDJ-KQ12073 | Human | 386678 | Details Get a Quote |
| KRTAP10-11 Knockout HeLa Cell Line | EDJ-KQ59958 | Human | 386678 | Details Get a Quote |
| KRTAP10-11 Knockout A-549 Cell Line | EDJ-KQ68419 | Human | 386678 | Details Get a Quote |
| KRTAP10-11 Knockout HCT 116 Cell Line | EDJ-KQ76798 | Human | 386678 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
