KRT222: Keratin 222
A type II keratin gene with limited functional characterization
Gene Information Card
| Symbol | KRT222 |
|---|---|
| Full Name | keratin 222 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.2 |
| NCBI Gene ID | 100507246 ncbi.nlm.nih.gov/gene/100507246 |
| Ensembl ID | ENSG00000267280 |
| UniProt ID | A0A0C4DH68 |
| OMIM ID | 618930 |
| HGNC ID | 53719 |
| Aliases | KRT222P, KRT222-like |
Description
KRT222 (keratin 222) is a protein-coding gene located on chromosome 17q21.2. It belongs to the type II keratin family of intermediate filament proteins. The gene is primarily expressed in certain epithelial tissues and has been implicated in hair follicle development and epidermal differentiation. Limited functional data are available; further studies are needed to clarify its precise biological role.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 0.8 | Low |
| Esophagus | 0.5 | Low |
| Breast | 0.3 | Low |
| Prostate | 0.2 | Low |
| Thyroid | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HaCaT (keratinocytes) | 0.6 | Low expression |
| A431 (epidermoid carcinoma) | 0.4 | Low expression |
| MCF7 (breast cancer) | 0.1 | Not detected |
| HeLa (cervical cancer) | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations reported
Gain of Function (GOF)
No gain-of-function mutations reported
Dominant Negative (DN)
No dominant-negative mutations reported
View complete mutation data：
Gene Ontology (GO)
| • intermediate filament | • structural molecule activity |
| • keratin filament |
Pathways
• Intermediate filament organization
• Keratinization
Protein Summary
Keratin 222 is a type II keratin intermediate filament protein. It is predicted to form heteropolymers with type I keratins and contribute to the structural integrity of epithelial cells. The protein sequence contains a central alpha-helical rod domain characteristic of intermediate filament proteins. Expression data suggest a role in skin and other stratified epithelia, but detailed functional studies are lacking.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KRT222 Knockout HEK293 Cell Line | EDJ-KQ8740 | Human | 125113 | Details Get a Quote |
| KRT222 Knockout A-549 Cell Line | EDJ-KQ34987 | Human | 125113 | Details Get a Quote |
| KRT222 Knockout HCT 116 Cell Line | EDJ-KQ33725 | Human | 125113 | Details Get a Quote |
| KRT222 Knockout HeLa Cell Line | EDJ-KQ58150 | Human | 125113 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
