KLF17: Kruppel-like Factor 17
A transcriptional regulator involved in embryonic development and cancer metastasis suppression.
Gene Information Card
| Symbol | KLF17 |
|---|---|
| Full Name | Kruppel-like factor 17 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p34.1 |
| NCBI Gene ID | 57585 ncbi.nlm.nih.gov/gene/57585 |
| Ensembl ID | ENSG00000162614 |
| UniProt ID | Q5T8P6 |
| OMIM ID | 609393 |
| HGNC ID | 18815 |
| Aliases | ZNF393, Zfp393, FLJ23468 |
Description
KLF17 (Kruppel-like factor 17) is a protein-coding gene that encodes a zinc finger transcription factor belonging to the Kruppel-like factor (KLF) family. It plays a role in regulating gene expression during embryonic development and has been implicated as a suppressor of epithelial-mesenchymal transition (EMT) and cancer metastasis, particularly in breast cancer. KLF17 is also involved in trophoblast differentiation and placental development.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | KLF17 suppresses EMT and metastasis by regulating the transcription of target genes such as Id1; loss of KLF17 expression correlates with increased metastatic potential. | PMID: 19377476; NCBI Gene |
| Placental development disorders | KLF17 is expressed in trophoblast cells and may regulate trophoblast invasion and differentiation; dysregulation linked to preeclampsia. | PMID: 23376485; UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 12.5 | Medium |
| Testis | 8.2 | Low |
| Breast | 4.1 | Low |
| Lung | 2.3 | Not detected |
| Liver | 1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 3.5 | Low expression |
| HEK293 (embryonic kidney) | 2.1 | Very low |
| JEG-3 (choriocarcinoma) | 15.0 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown functional effect; reported in COSMIC |
| c.632delG (p.Gly211Valfs*12) | Frameshift deletion | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the zinc finger domain are predicted to cause loss of transcriptional repressor activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported in KLF17.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for KLF17.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Epithelial-to-mesenchymal transition (EMT) regulation
• Trophoblast differentiation pathway
Protein Summary
KLF17 is a 391-amino acid nuclear protein containing three C2H2-type zinc finger domains at the C-terminus, which mediate sequence-specific DNA binding. It functions primarily as a transcriptional repressor, regulating genes involved in cell migration, invasion, and differentiation. KLF17 is highly expressed in placenta and testis, with lower levels in other tissues. Its role in suppressing breast cancer metastasis by inhibiting Id1 expression has been well documented.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KLF17 Knockout HEK293 Cell Line | EDJ-KQ9151 | Human | 128209 | Details Get a Quote |
| KLF17 Knockout HeLa Cell Line | EDJ-KQ58226 | Human | 128209 | Details Get a Quote |
| KLF17 Knockout A-549 Cell Line | EDJ-KQ66713 | Human | 128209 | Details Get a Quote |
| KLF17 Knockout HCT 116 Cell Line | EDJ-KQ75125 | Human | 128209 | Details Get a Quote |
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