KLF10 Gene - Kruppel Like Factor 10
Transcriptional regulator involved in TGF-beta signaling and cellular differentiation
Gene Information Card
| Symbol | KLF10 |
|---|---|
| Full Name | Kruppel Like Factor 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 8q22.3 |
| NCBI Gene ID | 7071 ncbi.nlm.nih.gov/gene/7071 |
| Ensembl ID | ENSG00000104447 |
| UniProt ID | Q13118 |
| OMIM ID | 601878 |
| HGNC ID | 11810 |
| Aliases | TIEG1, EGR-alpha, TIEG, EGRA |
Description
KLF10 (Kruppel Like Factor 10), also known as TIEG1 (TGF-beta Inducible Early Growth Response 1), is a transcription factor that belongs to the Sp/KLF family. It contains three C2H2-type zinc finger domains and is induced by TGF-beta, BMP, and other growth factors. KLF10 regulates cell proliferation, differentiation, and apoptosis, and plays a role in bone development, immune response, and tumor suppression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic cancer | Loss of KLF10 expression leads to increased cell proliferation and reduced apoptosis via TGF-beta signaling dysregulation | COSMIC, ClinVar |
| Breast cancer | KLF10 acts as a tumor suppressor; promoter methylation and reduced expression are associated with poor prognosis | NCBI Gene, ClinVar |
| Osteoporosis | KLF10 regulates osteoblast differentiation; knockout mice show reduced bone mass | OMIM, NCBI Gene |
| Corneal dystrophy | Mutations in KLF10 are associated with corneal endothelial dystrophy | ClinVar, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 12.5 | Medium |
| Bone marrow | 8.3 | Low |
| Spleen | 15.2 | Medium |
| Lung | 6.7 | Low |
| Kidney | 9.1 | Low |
| Liver | 4.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.4 | Cervical cancer cell line |
| MCF7 | 22.1 | Breast cancer cell line |
| A549 | 14.7 | Lung cancer cell line |
| K562 | 11.3 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | 0.01% | p.Met1Val; likely loss of function |
| c.457C>T | Nonsense | 0.02% | p.Arg153*; premature truncation |
| c.1024G>A | Missense | 0.005% | p.Gly342Arg; altered DNA binding |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations leading to truncated protein or nonsense-mediated decay; reduced transcriptional activity.
Gain of Function (GOF)
Not well documented; rare missense variants may enhance stability but no confirmed gain-of-function reported.
Dominant Negative (DN)
Not reported for KLF10.
View complete mutation data：
Gene Ontology (GO)
Pathways
• TGF-beta signaling pathway (Reactome: R-HSA-2173789)
• Transcriptional regulation by KLF10 (Reactome: R-HSA-9616222)
• BMP signaling pathway (KEGG: hsa04350)
Protein Summary
KLF10 encodes a 480-amino acid protein with three C2H2-type zinc finger domains at the C-terminus. It functions as a transcriptional repressor or activator depending on context. The protein is induced by TGF-beta and mediates growth inhibition by upregulating p21 and downregulating c-Myc. It also interacts with SMAD proteins to modulate TGF-beta signaling. Post-translational modifications include phosphorylation and ubiquitination.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KLF10 Knockout HEK293 Cell Line | EDJ-KQ2323 | Human | 7071 | Details Get a Quote |
| KLF10 Knockout A-549 Cell Line | EDJ-KQ22714 | Human | 7071 | Details Get a Quote |
| KLF10 Knockout HCT 116 Cell Line | EDJ-KQ22715 | Human | 7071 | Details Get a Quote |
| KLF10 Knockout HeLa Cell Line | EDJ-KQ22716 | Human | 7071 | Details Get a Quote |
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