KIF25: Kinesin Family Member 25
A kinesin motor protein involved in intracellular transport and potential implications in ciliopathy and cancer.
Gene Information Card
| Symbol | KIF25 |
|---|---|
| Full Name | kinesin family member 25 |
| Gene Type | protein-coding |
| Chromosomal Location | 6q27 |
| NCBI Gene ID | 3834 ncbi.nlm.nih.gov/gene/3834 |
| Ensembl ID | ENSG00000112210 |
| UniProt ID | Q9UIL4 |
| OMIM ID | 607923 |
| HGNC ID | 6392 |
| Aliases | KNSL3, KIF25A |
Description
KIF25 (kinesin family member 25) encodes a member of the kinesin superfamily of microtubule-based motor proteins. Kinesins play essential roles in intracellular transport, cell division, and ciliary function. KIF25 is specifically implicated in ciliary transport and may have a role in tumor suppression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Ciliopathy (retinitis pigmentosa, nephronophthisis) | Defective ciliary transport due to KIF25 loss-of-function mutations | OMIM #607923; ClinVar |
| Breast cancer | Reduced KIF25 expression associated with tumor progression | COSMIC; NCBI GeneRIF |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Kidney | 6.1 | Low |
| Lung | 4.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.8 | Embryonic kidney cells |
| HeLa | 7.2 | Cervical cancer cells |
| MCF7 | 3.1 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1042C>T (p.Arg348*) | Nonsense | Rare | Loss of function; associated with ciliopathy |
| c.157G>A (p.Glu53Lys) | Missense | 0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in KIF25 lead to truncated protein, impairing ciliary transport and causing ciliopathy phenotypes.
Gain of Function (GOF)
No gain-of-function mutations reported for KIF25.
Dominant Negative (DN)
No dominant-negative mutations reported for KIF25.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Intraflagellar transport (IFT)
• Cargo trafficking along microtubules
Protein Summary
KIF25 is a kinesin motor protein that uses ATP hydrolysis to move along microtubules, primarily involved in intraflagellar transport (IFT) within cilia. It is essential for proper ciliary assembly and function. Loss of KIF25 function leads to ciliopathy disorders such as retinitis pigmentosa and nephronophthisis. Reduced expression has also been observed in certain cancers, suggesting a potential tumor suppressor role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KIF25 Knockout HEK293 Cell Line | EDJ-KQ5078 | Human | 3834 | Details Get a Quote |
| KIF25 Knockout HeLa Cell Line | EDJ-KQ53750 | Human | 3834 | Details Get a Quote |
| KIF25 Knockout A-549 Cell Line | EDJ-KQ62227 | Human | 3834 | Details Get a Quote |
| KIF25 Knockout HCT 116 Cell Line | EDJ-KQ70711 | Human | 3834 | Details Get a Quote |
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