KIF13B Gene: Kinesin Family Member 13B - Function, Mutations & Disease

KIF13B encodes a member of the kinesin-3 family of microtubule-based motor proteins. The protein is involved in intracellular transport, including the movement of vesicles, organelles, and signaling molecules along microtubules. It plays roles in cell polarity, neuronal development, and immune cell function. Mutations and altered expression have been implicated in neurodevelopmental disorders and cancer.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Kinesin-mediated transport

• Microtubule-based movement

• Vesicle trafficking

• Neurotransmitter receptor transport

KIF13B is a kinesin-3 family motor protein that moves cargo along microtubules toward the plus end. It contains an N-terminal motor domain with ATPase activity, a coiled-coil stalk, and a C-terminal cargo-binding domain. The protein is essential for transporting vesicles, including those carrying signaling receptors, to the cell periphery. In neurons, it facilitates dendritic and axonal transport, influencing synaptic plasticity. In immune cells, it regulates T-cell receptor recycling. Dysregulation is linked to neurodevelopmental disorders and cancer metastasis.