KHNYN Gene
KHNYN: A Zinc Finger Protein Involved in RNA Metabolism and Antiviral Defense
Gene Information Card
| Symbol | KHNYN |
|---|---|
| Full Name | KH and NYN domain containing |
| Gene Type | Protein coding |
| Chromosomal Location | 14q32.2 |
| NCBI Gene ID | 100526760 ncbi.nlm.nih.gov/gene/100526760 |
| Ensembl ID | ENSG00000204104 |
| UniProt ID | Q6P3W7 |
| OMIM ID | 619200 |
| HGNC ID | 44249 |
| Aliases | FLJ45831, MGC16384 |
Description
KHNYN is a protein-coding gene that encodes a zinc finger protein containing a KH domain and an NYN domain. The protein is involved in RNA metabolism, including RNA binding and endoribonuclease activity, and plays a role in antiviral defense by restricting retroviruses such as HIV-1. It interacts with zinc finger antiviral protein (ZAP) to degrade viral RNA.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in OMIM, ClinVar, or COSMIC as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Spleen | 8.2 | Low |
| Lung | 6.1 | Low |
| Kidney | 5.4 | Low |
| Liver | 3.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.3 | Moderate expression |
| HeLa | 7.8 | Low expression |
| K562 | 5.2 | Low expression |
| HepG2 | 4.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in human disease.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
No documented dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding (GO:0003723) | • Endoribonuclease activity (GO:0004521) |
| • Zinc ion binding (GO:0008270) | • Antiviral defense (GO:0051607) |
| • RNA catabolic process (GO:0006401) |
Pathways
• Antiviral mechanism by ZAP (Reactome: R-HSA-168276)
Protein Summary
KHNYN is a 597-amino acid protein with a molecular weight of approximately 67 kDa. It contains a KH domain (involved in RNA binding) and an NYN domain (endoribonuclease). The protein localizes to the cytoplasm and is part of the ZAP-mediated antiviral pathway, targeting viral RNA for degradation. Its expression is highest in testis and spleen.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KHNYN Knockout HEK293 Cell Line | EDJ-KQ51097 | Human | 23351 | Details Get a Quote |
| KHNYN Knockout HeLa Cell Line | EDJ-KQ55722 | Human | 23351 | Details Get a Quote |
| KHNYN Knockout A-549 Cell Line | EDJ-KQ64221 | Human | 23351 | Details Get a Quote |
| KHNYN Knockout HCT 116 Cell Line | EDJ-KQ72667 | Human | 23351 | Details Get a Quote |
