KCNK10
Potassium Two Pore Domain Channel Subfamily K Member 10
Gene Information Card
| Symbol | KCNK10 |
|---|---|
| Full Name | Potassium Two Pore Domain Channel Subfamily K Member 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q31.3 |
| NCBI Gene ID | 54207 ncbi.nlm.nih.gov/gene/54207 |
| Ensembl ID | ENSG00000100427 |
| UniProt ID | P57789 |
| OMIM ID | 605873 |
| HGNC ID | 6278 |
| Aliases | K2P10.1, TREK-2, TREK2 |
Description
KCNK10 encodes a member of the two-pore domain potassium channel family, specifically the TREK-2 (K2P10.1) channel. This channel is a background potassium channel that contributes to the resting membrane potential and is regulated by various stimuli including mechanical stretch, intracellular pH, temperature, and volatile anesthetics. It is expressed in multiple tissues, with highest levels in the brain, and plays roles in neuronal excitability, pain perception, and neuroprotection.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bipolar Disorder | Altered KCNK10 expression may affect neuronal excitability and mood regulation; genetic association studies have linked polymorphisms to bipolar disorder. | Evidence from case-control studies (PMID: 21572416) and GWAS (PMID: 21926972). |
| Major Depressive Disorder | Variants in KCNK10 may contribute to altered stress response and depressive phenotypes. | Association reported in genetic studies (PMID: 21926972). |
| Pain Disorders | TREK-2 channels modulate nociceptor excitability; dysregulation may contribute to chronic pain states. | Functional studies in animal models (PMID: 16990514). |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Heart | 2.1 | Low |
| Kidney | 1.8 | Low |
| Lung | 1.5 | Low |
| Liver | 0.8 | Not detected |
| Skeletal Muscle | 0.6 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 8.3 | Neuroblastoma cell line |
| HEK293 | 0.2 | Low endogenous expression |
| U-87 MG | 4.1 | Glioblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown functional effect; rare variant in population databases. |
| c.688G>A (p.Val230Ile) | Missense | <0.01% | Reported in ClinVar as uncertain significance. |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations have been reported in KCNK10.
Gain of Function (GOF)
No well-characterized gain-of-function mutations have been reported in KCNK10.
Dominant Negative (DN)
No dominant-negative mutations have been described for KCNK10.
View complete mutation data：
Gene Ontology (GO)
| • inward rectifier potassium channel activity (GO:0005242) | • potassium channel activity (GO:0005267) |
| • outward rectifier potassium channel activity (GO:0015271) | • potassium ion transport (GO:0006813) |
| • potassium ion transmembrane transport (GO:0071805) | • integral component of membrane (GO:0016021) |
Pathways
• Potassium Channels (Reactome: R-HSA-1296071)
• Voltage gated Potassium channels (KEGG: hsa04010)
Protein Summary
The TREK-2 (K2P10.1) protein is a 538-amino acid two-pore domain potassium channel with four transmembrane segments and two pore-forming loops. It forms homodimers and functions as a background potassium channel that is activated by membrane stretch, intracellular acidosis, heat, and arachidonic acid. The channel is inhibited by G-protein coupled receptor signaling and is a target for volatile anesthetics. It is highly expressed in the central nervous system, particularly in the cortex, hippocampus, and cerebellum, where it regulates neuronal excitability and neurotransmitter release.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KCNK10 Knockout HEK293 Cell Line | EDJ-KQ11395 | Human | 54207 | Details Get a Quote |
| KCNK10 Knockout HeLa Cell Line | EDJ-KQ56401 | Human | 54207 | Details Get a Quote |
| KCNK10 Knockout A-549 Cell Line | EDJ-KQ64893 | Human | 54207 | Details Get a Quote |
| KCNK10 Knockout HCT 116 Cell Line | EDJ-KQ73337 | Human | 54207 | Details Get a Quote |
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