JUN
Jun proto-oncogene, AP-1 transcription factor subunit
Gene Information Card
| Symbol | JUN |
|---|---|
| Full Name | Jun proto-oncogene, AP-1 transcription factor subunit |
| Gene Type | protein-coding |
| Chromosomal Location | 1p32.1 |
| NCBI Gene ID | 3725 ncbi.nlm.nih.gov/gene/3725 |
| Ensembl ID | ENSG00000177606 |
| UniProt ID | P05412 |
| OMIM ID | 165160 |
| HGNC ID | 6204 |
| Aliases | AP-1, c-Jun, p39 |
Description
JUN is a proto-oncogene encoding the c-Jun protein, a key component of the AP-1 transcription factor complex. It regulates gene expression in response to various stimuli, including growth factors, cytokines, and stress signals, and is involved in cell proliferation, differentiation, and apoptosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression or constitutive activation of JUN promotes cell proliferation and tumorigenesis | PMID: 10647931 |
| Rheumatoid arthritis | JUN/AP-1 activation drives inflammatory cytokine production in synovial fibroblasts | PMID: 11733568 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Liver | 8.3 | Low |
| Brain | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| A549 | 18.7 | Lung cancer cell line |
| HEK293 | 10.4 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| p.Ser63Ala | Missense | <0.01% | Altered phosphorylation |
Mutation functional classification
Loss of Function (LOF)
Not commonly reported; JUN is primarily oncogenic.
Gain of Function (GOF)
Overexpression or mutations enhancing transcriptional activity contribute to oncogenesis.
Dominant Negative (DN)
Engineered dominant-negative mutants (e.g., TAM67) inhibit AP-1 activity.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| • protein heterodimerization activity |
Pathways
• MAPK signaling pathway
• TNF signaling pathway
• IL-17 signaling pathway
Protein Summary
c-Jun is a 39 kDa nuclear protein that dimerizes with Fos family members to form the AP-1 transcription factor. It contains a basic leucine zipper (bZIP) domain for DNA binding and dimerization. Phosphorylation by JNK kinases regulates its stability and transcriptional activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| JUN Knockout HEK293 Cell Line | EDJ-KQ176 | Human | 3725 | Details Get a Quote |
| JUN Knockout HEK293T Cell Line | EDJ-KQ184 | Human | 3725 | Details Get a Quote |
| JUN Knockout A-549 Cell Line | EDJ-KQ19217 | Human | 3725 | Details Get a Quote |
| JUN Knockout HCT 116 Cell Line | EDJ-KQ19219 | Human | 3725 | Details Get a Quote |
| JUN Knockout HeLa Cell Line | EDJ-KQ19220 | Human | 3725 | Details Get a Quote |
| JUND Knockout HEK293 Cell Line | EDJ-KQ50402 | Human | 3727 | Details Get a Quote |
| JUND Knockout HeLa Cell Line | EDJ-KQ53691 | Human | 3727 | Details Get a Quote |
| JUND Knockout A-549 Cell Line | EDJ-KQ62168 | Human | 3727 | Details Get a Quote |
| JUND Knockout HCT 116 Cell Line | EDJ-KQ70654 | Human | 3727 | Details Get a Quote |
| JUN Knockout HAP1 Cell Line | EDC08198 | Human | 3725 | Details Get a Quote |
Displaying Records 1 To 10 Of 10 Records
