INTS15: Integrator Complex Subunit 15
A component of the Integrator complex involved in snRNA 3'-end processing and transcriptional regulation.
Gene Information Card
| Symbol | INTS15 |
|---|---|
| Full Name | Integrator Complex Subunit 15 |
| Gene Type | Protein coding |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000185862 |
| UniProt ID | Q96N58 |
| OMIM ID | 615526 |
| HGNC ID | 25242 |
| Aliases | C7orf26, INT15, FLJ32642 |
Description
INTS15 encodes a subunit of the Integrator complex, which is essential for the 3'-end processing of small nuclear RNAs (snRNAs) and modulates RNA polymerase II transcription. The protein localizes to the nucleus and interacts with other Integrator subunits to facilitate cleavage and termination of snRNA transcripts. INTS15 is also implicated in DNA repair and cell cycle regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neurodevelopmental disorder with hypotonia and brain abnormalities | Loss-of-function mutations in INTS15 disrupt Integrator complex assembly, impairing snRNA processing and neuronal gene expression. | ClinVar, OMIM |
| Breast cancer | Somatic mutations and copy number alterations in INTS15 may affect transcriptional regulation of oncogenes and tumor suppressors. | COSMIC, NCBI |
| Lung adenocarcinoma | Recurrent missense mutations in INTS15 are associated with altered splicing and proliferation. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 6.1 | Low |
| Breast | 5.4 | Low |
| Liver | 4.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.8 | Embryonic kidney cells; moderate expression |
| HeLa | 7.2 | Cervical carcinoma; low expression |
| A549 | 6.5 | Lung carcinoma; low expression |
| MCF7 | 5.1 | Breast cancer; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1042C>T (p.Arg348*) | Nonsense | Rare | Loss of function; truncation of protein |
| c.157G>A (p.Gly53Arg) | Missense | 0.01% | Unknown; possibly damaging |
| c.2035_2036insA (p.Leu679fs) | Frameshift | Rare | Loss of function; premature stop |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in INTS15 lead to truncated or absent protein, impairing Integrator complex function and snRNA processing.
Gain of Function (GOF)
No gain-of-function mutations reported for INTS15.
Dominant Negative (DN)
No dominant-negative mutations reported for INTS15.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Integrator complex pathway
• snRNA 3'-end processing
• RNA polymerase II transcription termination
Protein Summary
INTS15 is a 748-amino acid nuclear protein that forms part of the Integrator complex. It contains no known enzymatic domains but is essential for complex stability and recruitment to snRNA genes. The protein interacts with INTS1 and INTS4 to mediate cleavage of nascent snRNA transcripts. INTS15 also participates in DNA damage response by facilitating transcription-coupled repair.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| INTS15 Knockout HEK293 Cell Line | EDJ-KQ13850 | Human | 79034 | Details Get a Quote |
| INTS15 Knockout A-549 Cell Line | EDJ-KQ43692 | Human | 79034 | Details Get a Quote |
| INTS15 Knockout HCT 116 Cell Line | EDJ-KQ43693 | Human | 79034 | Details Get a Quote |
| INTS15 Knockout HeLa Cell Line | EDJ-KQ43694 | Human | 79034 | Details Get a Quote |
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