INMT Gene - Indolethylamine N-Methyltransferase
Comprehensive gene card for INMT, including expression, mutations, and disease associations.
Gene Information Card
| Symbol | INMT |
|---|---|
| Full Name | Indolethylamine N-Methyltransferase |
| Gene Type | Protein coding |
| Chromosomal Location | 7p14.3 |
| NCBI Gene ID | 11185 ncbi.nlm.nih.gov/gene/11185 |
| Ensembl ID | ENSG00000105974 |
| UniProt ID | O95050 |
| OMIM ID | 606854 |
| HGNC ID | 6067 |
| Aliases | INMT1, TEMT |
Description
The INMT gene encodes indolethylamine N-methyltransferase, an enzyme that catalyzes the N-methylation of indoleamines such as tryptamine and serotonin. This methylation is involved in the metabolism of neurotransmitters and trace amines, and has been implicated in neurological disorders and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | Altered methylation of tryptamine may affect neurotransmitter balance | PMID: 12377270 |
| Major Depressive Disorder | Dysregulation of INMT expression in brain regions linked to mood | PMID: 23453820 |
| Colorectal Cancer | INMT hypermethylation and reduced expression observed in tumors | PMID: 25656847 |
| Lung Cancer | Epigenetic silencing of INMT via promoter methylation | PMID: 27323851 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.3 | Medium |
| Kidney | 8.7 | Medium |
| Brain (cerebellum) | 5.1 | Low |
| Lung | 3.2 | Low |
| Colon | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.6 | Hepatocellular carcinoma cell line |
| HEK293 | 9.4 | Embryonic kidney cells |
| SH-SY5Y | 6.2 | Neuroblastoma cell line |
| A549 | 3.1 | Lung adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.236G>A (p.Arg79His) | Missense | 0.0002 | Reduced enzyme activity in vitro |
| c.487C>T (p.Arg163Trp) | Missense | 0.0001 | Altered substrate specificity |
| c.1A>G (p.Met1Val) | Start loss | <0.0001 | Loss of protein expression |
Mutation functional classification
Loss of Function (LOF)
p.Met1Val and p.Arg79His reduce or abolish enzymatic activity.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • N-methyltransferase activity (GO:0008171) | • Cytoplasm (GO:0005737) |
| • Tryptophan catabolic process (GO:0006569) | • Indolalkylamine metabolic process (GO:0006586) |
Pathways
• ['Tryptophan metabolism'
• 'Reactome: R-HSA-71240']
• ['Neurotransmitter clearance'
• 'Reactome: R-HSA-112311']
Protein Summary
Indolethylamine N-methyltransferase (INMT) is a 29 kDa cytosolic enzyme that methylates indoleamines using S-adenosylmethionine as a methyl donor. It is highly expressed in liver and kidney, with lower levels in brain and lung. INMT plays a role in the metabolism of trace amines and has been linked to psychiatric disorders and cancer through epigenetic silencing.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| INMT Knockout HEK293 Cell Line | EDJ-KQ3926 | Human | 11185 | Details Get a Quote |
| INMT Knockout HeLa Cell Line | EDJ-KQ55598 | Human | 11185 | Details Get a Quote |
| INMT Knockout A-549 Cell Line | EDJ-KQ64094 | Human | 11185 | Details Get a Quote |
| INMT Knockout HCT 116 Cell Line | EDJ-KQ72544 | Human | 11185 | Details Get a Quote |
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