INCA1 (Inhibitor of CDK, Cyclin A1 Interacting Protein 1)
A negative regulator of CDK-cyclin complexes involved in cell cycle control and tumor suppression.
Gene Information Card
| Symbol | INCA1 |
|---|---|
| Full Name | Inhibitor of CDK, Cyclin A1 Interacting Protein 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 100506334 ncbi.nlm.nih.gov/gene/100506334 |
| Ensembl ID | ENSG00000267508 |
| UniProt ID | A0A1B0GTV6 |
| OMIM ID | 619216 |
| HGNC ID | 44238 |
| Aliases | C17orf104, FLJ45831 |
Description
INCA1 (Inhibitor of CDK, Cyclin A1 Interacting Protein 1) is a protein-coding gene located on chromosome 17p13.1. The encoded protein interacts with cyclin A1 and inhibits CDK-cyclin complexes, thereby negatively regulating cell cycle progression. INCA1 is considered a potential tumor suppressor, with reduced expression observed in several cancer types.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Reduced INCA1 expression leads to loss of CDK inhibition, promoting uncontrolled cell proliferation. | PMID: 31073040 |
| Lung cancer | Downregulation of INCA1 correlates with poor prognosis and increased tumor growth. | PMID: 31514209 |
| Colorectal cancer | INCA1 silencing via promoter methylation contributes to tumorigenesis. | PMID: 32041687 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.3 | Low |
| Lung | 4.1 | Low |
| Breast | 3.9 | Low |
| Colon | 2.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 5.2 | Reduced compared to normal breast tissue |
| A549 (lung cancer) | 3.8 | Low expression associated with aggressive phenotype |
| HCT116 (colorectal cancer) | 2.1 | Methylation-mediated silencing |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.152C>T (p.Pro51Leu) | Missense | <0.1% | Unknown functional impact |
| c.89delA (p.Asn30Thrfs*2) | Frameshift | <0.1% | Predicted loss of function |
| c.203G>A (p.Arg68His) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.89delA) are predicted to cause premature truncation and loss of CDK-inhibitory activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Cell Cycle (Reactome: R-HSA-1640170)
• p53-independent G1/S DNA damage checkpoint (Reactome: R-HSA-69620)
Protein Summary
The INCA1 protein is a 152-amino-acid polypeptide that contains a conserved CDK-binding domain. It interacts specifically with cyclin A1 and inhibits CDK2/cyclin A1 kinase activity, thereby blocking G1/S transition. INCA1 also binds histone deacetylases, suggesting a role in chromatin remodeling and transcriptional regulation. Loss of INCA1 expression is observed in multiple cancers, supporting its function as a tumor suppressor.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| INCA1 Knockout HEK293 Cell Line | EDJ-KQ13836 | Human | 388324 | Details Get a Quote |
| INCA1 Knockout HeLa Cell Line | EDJ-KQ42398 | Human | 388324 | Details Get a Quote |
| INCA1 Knockout A-549 Cell Line | EDJ-KQ43668 | Human | 388324 | Details Get a Quote |
| INCA1 Knockout HCT 116 Cell Line | EDJ-KQ76853 | Human | 388324 | Details Get a Quote |
