IL25
Interleukin 25
Gene Information Card
| Symbol | IL25 |
|---|---|
| Full Name | Interleukin 25 |
| Gene Type | protein-coding |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 64806 ncbi.nlm.nih.gov/gene/64806 |
| Ensembl ID | ENSG00000166092 |
| UniProt ID | Q9H293 |
| OMIM ID | 605658 |
| HGNC ID | 13765 |
| Aliases | IL-25, IL17E, UNQ3104/PRO10207 |
Description
IL25 (interleukin 25) is a cytokine belonging to the IL-17 family, also known as IL-17E. It is produced by various cell types including Th2 cells, mast cells, eosinophils, and epithelial cells. IL25 promotes type 2 immune responses by inducing the production of IL-4, IL-5, and IL-13, and plays a critical role in allergic inflammation, asthma, and host defense against helminth infections.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | IL25 drives Th2 cytokine production, leading to airway eosinophilia and hyperresponsiveness. | NCBI Gene, OMIM |
| Allergic rhinitis | IL25 enhances IgE production and eosinophil recruitment in nasal mucosa. | NCBI Gene, OMIM |
| Atopic dermatitis | IL25 expression is elevated in skin lesions, promoting type 2 inflammation. | NCBI Gene, OMIM |
| Helminth infection | IL25 is essential for expulsion of parasitic worms via Th2 responses. | NCBI Gene, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 0.8 | Low |
| Small intestine | 0.6 | Low |
| Colon | 0.5 | Low |
| Stomach | 0.4 | Low |
| Spleen | 0.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Th2 cells | 0.2 | Produced upon activation |
| Mast cells | 0.1 | Produced upon IgE cross-linking |
| Eosinophils | 0.1 | Produced upon activation |
| Epithelial cells | 0.1 | Constitutive low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | SNV | <0.01% | Not characterized |
| c.100C>T | SNV | <0.01% | Not characterized |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in COSMIC or ClinVar.
View complete mutation data：
Gene Ontology (GO)
| • cytokine activity (GO:0005125) | • extracellular space (GO:0005615) |
| • immune response (GO:0006955) | • cytokine-mediated signaling pathway (GO:0019221) |
| • innate immune response (GO:0045087) |
Pathways
• IL-17 signaling pathway (KEGG: hsa04657)
• Th17 cell differentiation (KEGG: hsa04659)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
Protein Summary
Interleukin 25 (IL-25) is a 177-amino acid protein with a signal peptide and a fibronectin type III domain. It forms a homodimer and signals through the IL-17RA/IL-17RB receptor complex, activating NF-kB and MAPK pathways. IL-25 is a key initiator of type 2 immunity and is implicated in allergic diseases and anti-helminth responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL25 Knockout HEK293 Cell Line | EDJ-KQ570 | Human | 64806 | Details Get a Quote |
| IL25 Knockout HeLa Cell Line | EDJ-KQ57084 | Human | 64806 | Details Get a Quote |
| IL25 Knockout A-549 Cell Line | EDJ-KQ65596 | Human | 64806 | Details Get a Quote |
| IL25 Knockout HCT 116 Cell Line | EDJ-KQ74025 | Human | 64806 | Details Get a Quote |
