IL20RA Gene: Interleukin 20 Receptor Subunit Alpha
Cytokine receptor in immune regulation and skin homeostasis
Gene Information Card
| Symbol | IL20RA |
|---|---|
| Full Name | Interleukin 20 Receptor Subunit Alpha |
| Gene Type | protein-coding |
| Chromosomal Location | 6q23.3 |
| NCBI Gene ID | 53832 ncbi.nlm.nih.gov/gene/53832 |
| Ensembl ID | ENSG00000112658 |
| UniProt ID | Q9UHF4 |
| OMIM ID | 605620 |
| HGNC ID | 5999 |
| Aliases | IL20R1, CRF2-8, ZCYTOR7 |
Description
IL20RA encodes the alpha subunit of the interleukin 20 receptor, a type II cytokine receptor. This receptor forms a heterodimer with IL20RB to bind IL-19, IL-20, and IL-24, mediating JAK-STAT signaling. IL20RA is involved in immune responses, skin development, and epithelial homeostasis. Dysregulation is linked to inflammatory and autoimmune diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Psoriasis | IL20RA signaling via IL-19/IL-20 promotes keratinocyte proliferation and inflammation; overexpression in psoriatic lesions | PMID: 11574544; OMIM 605620 |
| Rheumatoid Arthritis | IL20RA-mediated cytokine signaling contributes to synovial inflammation and joint destruction | PMID: 12847267; NCBI Gene |
| Inflammatory Bowel Disease | IL20RA variants associated with altered mucosal immune responses | ClinVar; GWAS catalog |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 12.5 | Medium |
| Lung | 8.3 | Low |
| Kidney | 6.1 | Low |
| Spleen | 4.7 | Low |
| Thymus | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HaCaT (keratinocyte) | 15.2 | High expression; relevant to psoriasis |
| A549 (lung epithelial) | 7.8 | Moderate expression |
| HEK293 (embryonic kidney) | 5.4 | Low expression |
| THP-1 (monocyte) | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.482G>A (p.Arg161Gln) | Missense | <0.01% | Unknown; ClinVar VUS |
| c.1045C>T (p.Arg349Trp) | Missense | <0.01% | Unknown; ClinVar VUS |
| c.1237G>A (p.Gly413Ser) | Missense | <0.01% | Unknown; ClinVar VUS |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No confirmed dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
| • interleukin-20 receptor activity | • cytokine receptor activity |
| • JAK-STAT signaling pathway | • inflammatory response |
| • cell surface receptor signaling pathway | • skin development |
Pathways
• IL-20 family signaling (Reactome R-HSA-8984722)
• JAK-STAT signaling (KEGG hsa04630)
• Cytokine-cytokine receptor interaction (KEGG hsa04060)
Protein Summary
IL20RA is a 553-amino acid transmembrane glycoprotein with an extracellular domain containing fibronectin type III repeats, a transmembrane domain, and a cytoplasmic tail with JAK-binding motifs. It heterodimerizes with IL20RB to form a functional receptor for IL-19, IL-20, and IL-24. Upon ligand binding, it activates JAK1/2 and STAT3, leading to gene transcription involved in cell proliferation, differentiation, and immune modulation. The protein is expressed predominantly in skin, lung, and immune tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL20RA Knockout HEK293 Cell Line | EDJ-KQ486 | Human | 53832 | Details Get a Quote |
| IL20RA Knockout HeLa Cell Line | EDJ-KQ56383 | Human | 53832 | Details Get a Quote |
| IL20RA Knockout A-549 Cell Line | EDJ-KQ64874 | Human | 53832 | Details Get a Quote |
| IL20RA Knockout HCT 116 Cell Line | EDJ-KQ73319 | Human | 53832 | Details Get a Quote |
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