IGDCC4
Immunoglobulin Superfamily DCC Subclass Member 4
Gene Information Card
| Symbol | IGDCC4 |
|---|---|
| Full Name | Immunoglobulin Superfamily DCC Subclass Member 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q31.1 |
| NCBI Gene ID | 57722 ncbi.nlm.nih.gov/gene/57722 |
| Ensembl ID | ENSG00000107104 |
| UniProt ID | Q8N6C5 |
| OMIM ID | 614564 |
| HGNC ID | 28978 |
| Aliases | DCC4, IGDCC4, PRO3401 |
Description
IGDCC4 (Immunoglobulin Superfamily DCC Subclass Member 4) is a protein-coding gene located on chromosome 9q31.1. The encoded protein belongs to the immunoglobulin superfamily and contains multiple immunoglobulin-like domains and fibronectin type III repeats. It is involved in cell adhesion and may play a role in neural development and cancer. Expression is enriched in brain and certain epithelial tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered expression; potential tumor suppressor role | COSMIC; NCBI Gene |
| Breast cancer | Downregulation observed in invasive subtypes | NCBI Gene; literature |
| Neuroblastoma | Possible involvement in neural crest cell migration | OMIM; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.2 | Low |
| Kidney | 6.7 | Low |
| Testis | 5.1 | Low |
| Colon | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.3 | Neuronal model |
| MCF7 (breast cancer) | 2.1 | Low expression |
| HCT116 (colorectal) | 3.8 | Moderate |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function; potential impact on protein integrity |
| c.567G>A (p.Trp189*) | Nonsense | <0.1% | Premature stop; likely loss of function |
| c.890A>G (p.Asn297Ser) | Missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (p.Arg412*, p.Trp189*) lead to truncated protein and loss of function.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion | • homophilic cell adhesion via plasma membrane adhesion molecules |
| • plasma membrane | • integral component of membrane |
| • immunoglobulin domain |
Pathways
• Cell adhesion molecules (CAMs)
• Neural crest cell migration
Protein Summary
The IGDCC4 protein is a single-pass type I membrane protein with 5 immunoglobulin-like C2-type domains and 3 fibronectin type III repeats. It is predicted to mediate cell-cell adhesion through homophilic interactions. The protein is expressed in neural tissues and may regulate axon guidance and cell migration. Its extracellular region is involved in ligand binding, while the cytoplasmic tail contains potential signaling motifs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IGDCC4 Knockout HEK293 Cell Line | EDJ-KQ3674 | Human | 57722 | Details Get a Quote |
| IGDCC4 Knockout A-549 Cell Line | EDJ-KQ25660 | Human | 57722 | Details Get a Quote |
| IGDCC4 Knockout HCT 116 Cell Line | EDJ-KQ25661 | Human | 57722 | Details Get a Quote |
| IGDCC4 Knockout HeLa Cell Line | EDJ-KQ56911 | Human | 57722 | Details Get a Quote |
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