IGDCC3
Immunoglobulin Superfamily DCC Subclass Member 3
Gene Information Card
| Symbol | IGDCC3 |
|---|---|
| Full Name | Immunoglobulin Superfamily DCC Subclass Member 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q13.31 |
| NCBI Gene ID | 9543 ncbi.nlm.nih.gov/gene/9543 |
| Ensembl ID | ENSG00000163823 |
| UniProt ID | Q8N6C5 |
| OMIM ID | 617695 |
| HGNC ID | 28926 |
| Aliases | IGDCC3, DCC3, PUNC |
Description
IGDCC3 (Immunoglobulin Superfamily DCC Subclass Member 3) is a protein-coding gene located on chromosome 3q13.31. It encodes a member of the immunoglobulin superfamily, structurally related to the deleted in colorectal carcinoma (DCC) family. The protein is involved in cell adhesion and may play a role in neural development and cancer. Expression is observed in various tissues, with notable levels in the brain and certain cancer cell lines.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Potential tumor suppressor; altered expression may contribute to tumorigenesis | COSMIC; limited studies |
| Breast Cancer | Downregulation observed in some subtypes; possible role in metastasis | COSMIC; expression data |
| Glioblastoma | Expression changes noted; potential involvement in neural tumor biology | COSMIC; expression data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.2 | Low |
| Breast | 6.1 | Low |
| Colon | 5.3 | Low |
| Kidney | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (Breast Cancer) | 8.9 | Moderate expression |
| A549 (Lung Cancer) | 7.3 | Low expression |
| HEK293 (Embryonic Kidney) | 6.5 | Low expression |
| U87MG (Glioblastoma) | 11.2 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function; predicted truncation |
| c.567G>A (p.Gly189Arg) | Missense | <0.1% | Unknown significance |
| c.890_891insA | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift variants likely lead to loss of function through premature termination or altered reading frame.
Gain of Function (GOF)
No evidence of gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects reported.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion | • plasma membrane |
| • immunoglobulin-like domain | • protein binding |
Pathways
• Cell adhesion molecules (CAMs)
• Netrin signaling (predicted)
Protein Summary
The IGDCC3 protein is a single-pass type I membrane protein containing immunoglobulin-like domains. It is predicted to function in cell-cell adhesion and may interact with netrin receptors. The protein is expressed in multiple tissues, with highest levels in the brain. Its role in cancer is under investigation, with some evidence suggesting tumor suppressor activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IGDCC3 Knockout HEK293 Cell Line | EDJ-KQ5970 | Human | 9543 | Details Get a Quote |
| IGDCC3 Knockout HeLa Cell Line | EDJ-KQ55190 | Human | 9543 | Details Get a Quote |
| IGDCC3 Knockout A-549 Cell Line | EDJ-KQ63672 | Human | 9543 | Details Get a Quote |
| IGDCC3 Knockout HCT 116 Cell Line | EDJ-KQ72134 | Human | 9543 | Details Get a Quote |
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