IGBP1C (Immunoglobulin Binding Protein 1C) Gene
A comprehensive biomedical overview of IGBP1C, including genomic context, expression, and disease associations.
Gene Information Card
| Symbol | IGBP1C |
|---|---|
| Full Name | Immunoglobulin Binding Protein 1C |
| Gene Type | Protein coding |
| Chromosomal Location | Xq13.1 |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000229807 |
| UniProt ID | A6NJT0 |
| OMIM ID | Not available |
| HGNC ID | HGNC:44277 |
| Aliases | IGBP1C, MGC16169 |
Description
IGBP1C (Immunoglobulin Binding Protein 1C) is a protein-coding gene located on the X chromosome at Xq13.1. It encodes a protein that is predicted to be involved in immunoglobulin binding, though its exact biological role remains under investigation. The gene is expressed in various tissues, with notable levels in the testis and certain brain regions. IGBP1C is part of the immunoglobulin binding protein family, which may play roles in immune response and protein trafficking. Further research is needed to fully elucidate its function and clinical significance.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No curated disease links found in OMIM or ClinVar as of current data. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.4 | Medium |
| Brain (cerebellum) | 5.2 | Low |
| Lung | 3.1 | Low |
| Spleen | 2.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 2.5 | Low expression |
| K562 | 1.8 | Low expression |
| MCF7 | 3.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not applicable | Not available | No functional data |
Mutation functional classification
Loss of Function (LOF)
No evidence available
Gain of Function (GOF)
No evidence available
Dominant Negative (DN)
No evidence available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • cytosol (GO:0005829) |
Pathways
• No curated pathways available
Protein Summary
The IGBP1C protein is a small, uncharacterized protein of approximately 200 amino acids. It contains an immunoglobulin-like domain, suggesting potential involvement in protein-protein interactions. Predicted to localize to the cytoplasm, it may participate in immune-related processes or cellular signaling. However, experimental validation is lacking, and its physiological role remains to be determined.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IGBP1C Knockout HEK293 Cell Line | EDJ-KQ13809 | Human | 645545 | Details Get a Quote |
| IGBP1C Knockout A-549 Cell Line | EDJ-KQ43619 | Human | 645545 | Details Get a Quote |
| IGBP1C Knockout HCT 116 Cell Line | EDJ-KQ43620 | Human | 645545 | Details Get a Quote |
| IGBP1C Knockout HeLa Cell Line | EDJ-KQ43621 | Human | 645545 | Details Get a Quote |
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