IFNA8: Interferon Alpha-8 Gene
Cytokine Gene in Antiviral and Immune Regulation
Gene Information Card
| Symbol | IFNA8 |
|---|---|
| Full Name | Interferon Alpha 8 |
| Gene Type | protein-coding |
| Chromosomal Location | 9p21.3 |
| NCBI Gene ID | 3440 ncbi.nlm.nih.gov/gene/3440 |
| Ensembl ID | ENSG00000120235 |
| UniProt ID | P32881 |
| OMIM ID | 147570 |
| HGNC ID | 5422 |
| Aliases | IFNA8, IFN-alpha-8, leIF A, interferon alpha-8 |
Description
IFNA8 (Interferon Alpha 8) is a protein-coding gene located on chromosome 9p21.3. It encodes a member of the type I interferon family, interferon alpha-8, which is secreted by immune cells in response to viral infections. This cytokine binds to the IFNAR1/IFNAR2 receptor complex, activating JAK-STAT signaling to induce an antiviral state, modulate immune responses, and inhibit cell proliferation. IFNA8 is part of a cluster of interferon alpha genes on chromosome 9.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatitis C Virus Infection | Reduced IFNA8 expression may impair antiviral response; polymorphisms associated with treatment outcome | ClinVar, NCBI |
| Systemic Lupus Erythematosus | Dysregulated type I interferon signaling including IFNA8 contributes to autoimmunity | OMIM, NCBI |
| Viral Infections (general) | IFNA8 mediates innate antiviral immunity through interferon-stimulated gene induction | UniProt, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.8 | Low |
| Lymph Node | 0.6 | Low |
| Bone Marrow | 0.5 | Low |
| Whole Blood | 0.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.2 | Low baseline expression |
| THP-1 | 1.5 | Induced by viral stimulation |
| PBMC | 2.0 | Induced by IFN-alpha or virus |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs10108980 | SNP | 0.15 (global) | Associated with altered interferon response |
| rs12568213 | SNP | 0.10 (global) | May affect gene expression |
Mutation functional classification
Loss of Function (LOF)
Rare nonsense or frameshift mutations predicted to truncate the protein, reducing antiviral activity.
Gain of Function (GOF)
Not well characterized; overexpression in certain contexts may enhance interferon signaling.
Dominant Negative (DN)
No known dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Interferon alpha/beta signaling (Reactome R-HSA-909733)
• Cytokine-cytokine receptor interaction (KEGG hsa04060)
• JAK-STAT signaling pathway (KEGG hsa04630)
Protein Summary
Interferon alpha-8 (IFNA8) is a 189-amino-acid secreted cytokine with a signal peptide (residues 1-23) and a mature chain (24-189). It belongs to the type I interferon family and shares structural homology with other IFN-alpha subtypes. The protein forms a five-helix bundle and binds to the IFNAR1/IFNAR2 receptor complex, triggering JAK1/TYK2 phosphorylation and STAT1/STAT2 activation. This leads to transcription of interferon-stimulated genes (ISGs) that inhibit viral replication and modulate immune responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFNA8 Knockout HEK293 Cell Line | EDJ-KQ471 | Human | 3445 | Details Get a Quote |
| IFNA8 Knockout HeLa Cell Line | EDJ-KQ53612 | Human | 3445 | Details Get a Quote |
| IFNA8 Knockout A-549 Cell Line | EDJ-KQ62082 | Human | 3445 | Details Get a Quote |
| IFNA8 Knockout HCT 116 Cell Line | EDJ-KQ70566 | Human | 3445 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
