ID1
Inhibitor of DNA Binding 1, HLH Protein
Gene Information Card
| Symbol | ID1 |
|---|---|
| Full Name | Inhibitor of DNA Binding 1, HLH Protein |
| Gene Type | protein-coding |
| Chromosomal Location | 20q11.21 |
| NCBI Gene ID | 3397 ncbi.nlm.nih.gov/gene/3397 |
| Ensembl ID | ENSG00000125968 |
| UniProt ID | P41134 |
| OMIM ID | 600349 |
| HGNC ID | 5360 |
| Aliases | ID, bHLHb24 |
Description
ID1 encodes a helix-loop-helix (HLH) protein that lacks a basic DNA-binding domain. It functions as a dominant-negative regulator of basic HLH transcription factors by forming heterodimers, thereby inhibiting DNA binding and transcriptional activation. ID1 plays a key role in cell growth, differentiation, senescence, and angiogenesis. Overexpression is associated with various cancers and poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | ID1 overexpression promotes epithelial-mesenchymal transition and metastasis | PMID: 20628086 |
| Prostate Cancer | ID1 upregulation correlates with androgen independence and tumor progression | PMID: 15159319 |
| Glioma | ID1 expression enhances tumor cell proliferation and invasion | PMID: 19137077 |
| Endometrial Cancer | ID1 overexpression linked to aggressive tumor phenotype | PMID: 21947063 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 0.6 | Not detected |
| Breast | 1.2 | Low |
| Prostate | 0.8 | Not detected |
| Brain | 0.5 | Not detected |
| Placenta | 4.3 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 | 1.5 | Low expression |
| PC3 | 2.1 | Low expression |
| U87MG | 3.8 | Medium expression |
| HepG2 | 0.9 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown |
| c.172C>T | missense | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
Overexpression is common in cancers; specific gain-of-function mutations are not well characterized.
Dominant Negative (DN)
ID1 acts as a natural dominant-negative regulator of bHLH transcription factors; no additional dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• hsa:04350 - TGF-beta signaling pathway
• hsa:04151 - PI3K-Akt signaling pathway
• hsa:05200 - Pathways in cancer
Protein Summary
ID1 is a 148-amino acid protein (16 kDa) belonging to the inhibitor of DNA binding family. It contains a helix-loop-helix domain but lacks a basic region, preventing direct DNA binding. ID1 heterodimerizes with E proteins (e.g., E12, E47) to sequester them from binding to E-box sequences, thereby inhibiting transcription of genes involved in differentiation. ID1 is highly expressed in embryonic tissues and certain cancers, where it promotes proliferation, angiogenesis, and metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ID1 Knockout HEK293 Cell Line | EDJ-KQ382 | Human | 3397 | Details Get a Quote |
| ID1 Knockout A-549 Cell Line | EDJ-KQ18589 | Human | 3397 | Details Get a Quote |
| ID1 Knockout HCT 116 Cell Line | EDJ-KQ18590 | Human | 3397 | Details Get a Quote |
| ID1 Knockout HeLa Cell Line | EDJ-KQ18591 | Human | 3397 | Details Get a Quote |
