HTATIP2
HIV-1 Tat Interactive Protein 2, a putative tumor suppressor and regulator of angiogenesis and apoptosis
Gene Information Card
| Symbol | HTATIP2 |
|---|---|
| Full Name | HIV-1 Tat Interactive Protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.1 |
| NCBI Gene ID | 10553 ncbi.nlm.nih.gov/gene/10553 |
| Ensembl ID | ENSG00000148773 |
| UniProt ID | Q9BUP3 |
| OMIM ID | 605628 |
| HGNC ID | 16897 |
| Aliases | TIP30, CC3, SDR44U1, TIP |
Description
HTATIP2 (HIV-1 Tat Interactive Protein 2) encodes a short-chain dehydrogenase/reductase family member that acts as a putative tumor suppressor. The protein interacts with HIV-1 Tat and modulates transcription, apoptosis, and angiogenesis. Reduced expression is associated with tumor progression and metastasis in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Loss of HTATIP2 expression promotes metastasis and angiogenesis | PMID: 14647414 |
| Breast cancer | Reduced HTATIP2 correlates with poor prognosis and increased invasion | PMID: 15604205 |
| Colorectal cancer | HTATIP2 downregulation linked to lymph node metastasis | PMID: 17909063 |
| Lung cancer | Epigenetic silencing of HTATIP2 contributes to tumor growth | PMID: 19137073 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 10.2 | Medium |
| Breast | 8.5 | Medium |
| Colon | 7.1 | Medium |
| Lung | 9.8 | Medium |
| Kidney | 6.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 12.4 | Hepatocellular carcinoma cell line |
| MCF7 | 9.1 | Breast cancer cell line |
| HCT116 | 7.8 | Colorectal carcinoma cell line |
| A549 | 10.5 | Lung adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | <1% | Unknown functional impact |
| c.487G>A (p.Gly163Arg) | Missense | <1% | Reported in COSMIC; potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Reduced expression or missense mutations may impair tumor suppressor activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • oxidoreductase activity | • protein binding |
| • apoptotic process | • negative regulation of angiogenesis |
| • regulation of transcription by RNA polymerase II |
Pathways
• p53 signaling pathway
• apoptosis
Protein Summary
HTATIP2 is a 242-amino acid protein belonging to the short-chain dehydrogenase/reductase superfamily. It localizes to the cytoplasm and nucleus, and its enzymatic activity is implicated in lipid metabolism. The protein inhibits angiogenesis and promotes apoptosis, partly through interaction with p53 and modulation of HIF-1α.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HTATIP2 Knockout HEK293 Cell Line | EDJ-KQ2516 | Human | 10553 | Details Get a Quote |
| HTATIP2 Knockout A-549 Cell Line | EDJ-KQ23120 | Human | 10553 | Details Get a Quote |
| HTATIP2 Knockout HCT 116 Cell Line | EDJ-KQ23121 | Human | 10553 | Details Get a Quote |
| HTATIP2 Knockout HeLa Cell Line | EDJ-KQ23122 | Human | 10553 | Details Get a Quote |
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