HNRNPAB
Heterogeneous Nuclear Ribonucleoprotein A/B
Gene Information Card
| Symbol | HNRNPAB |
|---|---|
| Full Name | Heterogeneous Nuclear Ribonucleoprotein A/B |
| Gene Type | Protein coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 3188 ncbi.nlm.nih.gov/gene/3188 |
| Ensembl ID | ENSG00000113595 |
| UniProt ID | Q99729 |
| OMIM ID | 604629 |
| HGNC ID | 5034 |
| Aliases | ABBP1, HNRPAB, hnRNP A/B, APOBEC1-binding protein 1 |
Description
HNRNPAB encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which binds RNA and participates in pre-mRNA processing, alternative splicing, and mRNA transport. The protein contains two RNA recognition motifs and a glycine-rich domain. It is ubiquitously expressed and has been implicated in transcriptional regulation, including as a co-repressor of APOBEC1 editing. HNRNPAB is associated with various cancers and autoimmune disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes cell proliferation and invasion via alternative splicing regulation | PMID: 25605242 |
| Hepatocellular carcinoma | Upregulation correlates with poor prognosis and metastasis | PMID: 29351289 |
| Systemic lupus erythematosus | Autoantibodies against HNRNPAB detected in patient sera | PMID: 10775190 |
| Colorectal cancer | HNRNPAB knockdown reduces tumor growth in xenograft models | PMID: 31019238 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 15.3 | Medium |
| Liver | 18.7 | Medium |
| Breast | 14.2 | Medium |
| Colon | 16.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 20.5 | Cervical cancer cell line |
| HepG2 | 22.3 | Hepatocellular carcinoma cell line |
| MCF7 | 18.9 | Breast cancer cell line |
| A549 | 17.4 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.457G>A (p.Glu153Lys) | Missense | <0.1% (COSMIC) | Unknown functional impact |
| c.784C>T (p.Arg262Trp) | Missense | <0.1% (COSMIC) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Processing of Capped Intron-Containing Pre-mRNA (Reactome: R-HSA-72203)
• mRNA Splicing - Major Pathway (Reactome: R-HSA-72163)
Protein Summary
HNRNPAB is a 331-amino acid protein with two RNA recognition motifs (RRM1 and RRM2) and a C-terminal glycine-rich domain. It shuttles between the nucleus and cytoplasm, binding to poly(A) and poly(U) sequences. The protein is involved in pre-mRNA splicing, stability, and transport. It also interacts with APOBEC1 to modulate RNA editing. Post-translational modifications include phosphorylation and arginine methylation, which regulate its localization and function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HNRNPAB Knockout HEK293 Cell Line | EDJ-KQ2201 | Human | 3182 | Details Get a Quote |
| HNRNPAB Knockout A-549 Cell Line | EDJ-KQ22443 | Human | 3182 | Details Get a Quote |
| HNRNPAB Knockout HCT 116 Cell Line | EDJ-KQ22444 | Human | 3182 | Details Get a Quote |
| HNRNPAB Knockout HeLa Cell Line | EDJ-KQ22445 | Human | 3182 | Details Get a Quote |
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