HNRNPA1L3 Gene: Pseudogene, Location, and Expression | Biomedical SEO

HNRNPA1L3 (Heterogeneous Nuclear Ribonucleoprotein A1 Like 3) is a processed pseudogene located on chromosome 10 at q11.23. It is derived from the functional HNRNPA1 gene through retrotransposition, meaning it lacks introns and has a poly-A tail remnant. As a pseudogene, it is not expected to produce a functional protein. Its genomic sequence is highly similar to HNRNPA1, but it contains frameshift mutations and premature stop codons that prevent translation. The biological significance of HNRNPA1L3 is primarily as a genomic remnant, though some pseudogenes can regulate their parent genes through mechanisms like competing for microRNA binding or generating small interfering RNAs.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No pathways are associated with HNRNPA1L3. Its parent gene HNRNPA1 is involved in mRNA processing

• transport

• and metabolism

• but the pseudogene itself has no known pathway participation.

HNRNPA1L3 does not produce a functional protein. It is classified as a processed pseudogene, which means it originated from a reverse-transcribed mRNA of the HNRNPA1 gene and integrated into the genome. The sequence contains multiple disruptions, including premature stop codons and frameshifts, rendering it non-coding. No protein product is detected in vivo, and it is not represented in protein databases such as UniProt.