HNRNPA1L2 Gene
Heterogeneous Nuclear Ribonucleoprotein A1 Like 2
Gene Information Card
| Symbol | HNRNPA1L2 |
|---|---|
| Full Name | Heterogeneous Nuclear Ribonucleoprotein A1 Like 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 13q14.3 |
| NCBI Gene ID | 144983 ncbi.nlm.nih.gov/gene/144983 |
| Ensembl ID | ENSG00000139618 |
| UniProt ID | Q32P51 |
| OMIM ID | Not assigned |
| HGNC ID | HGNC:24915 |
| Aliases | HNRPA1L2, hnRNP A1-like 2 |
Description
HNRNPA1L2 is a protein-coding gene that encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. The protein is involved in RNA processing, including pre-mRNA splicing, transport, and metabolism. It is a paralog of HNRNPA1 and is located on chromosome 13q14.3.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 3.1 | Low |
| Lung | 2.8 | Low |
| Liver | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.0 | Low expression |
| HeLa | 3.5 | Low expression |
| K562 | 2.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • RNA binding (GO:0003723) | • nucleus (GO:0005634) |
| • mRNA processing (GO:0006397) |
Pathways
• No curated pathways in Reactome or KEGG
Protein Summary
HNRNPA1L2 is a 320-amino acid protein that contains two RNA recognition motifs (RRMs) and a glycine-rich domain. It is predicted to bind RNA and participate in nuclear RNA metabolism. The protein is ubiquitously expressed at low levels, with highest expression in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HNRNPA1L2 Knockout HEK293 Cell Line | EDJ-KQ3606 | Human | 144983 | Details Get a Quote |
| HNRNPA1L2 Knockout HCT 116 Cell Line | EDJ-KQ24148 | Human | 144983 | Details Get a Quote |
| HNRNPA1L2 Knockout A-549 Cell Line | EDJ-KQ25520 | Human | 144983 | Details Get a Quote |
| HNRNPA1L2 Knockout HeLa Cell Line | EDJ-KQ25522 | Human | 144983 | Details Get a Quote |
