HMGN3: High Mobility Group Nucleosomal Binding Domain 3
A chromatin-associated protein involved in transcriptional regulation and cellular differentiation.
Gene Information Card
| Symbol | HMGN3 |
|---|---|
| Full Name | High Mobility Group Nucleosomal Binding Domain 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 6q14.1 |
| NCBI Gene ID | 9324 ncbi.nlm.nih.gov/gene/9324 |
| Ensembl ID | ENSG00000118418 |
| UniProt ID | Q15651 |
| OMIM ID | 604501 |
| HGNC ID | 4987 |
| Aliases | HMG-17, HMG17, HMG-17-like, HMG17L3 |
Description
HMGN3 encodes a member of the high mobility group N (HMGN) family of nucleosomal binding proteins. These proteins bind to nucleosomes and modulate chromatin structure and function, thereby influencing transcription, replication, and DNA repair. HMGN3 is expressed in various tissues and is implicated in cellular differentiation and development.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No direct evidence from ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.4 | Cervical adenocarcinoma |
| HEK293 | 9.8 | Embryonic kidney |
| K562 | 11.2 | Leukemia |
| HepG2 | 7.5 | Hepatocellular carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No significant mutations reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in COSMIC or ClinVar.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
No documented dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • nucleosome (GO:0000786) | • nucleus (GO:0005634) |
| • DNA binding (GO:0003677) | • histone binding (GO:0042393) |
| • chromatin remodeling (GO:0006338) | • regulation of transcription (GO:0006355) |
Pathways
• Chromatin organization (Reactome: R-HSA-4839726)
• Packaging Of Telomere Ends (Reactome: R-HSA-171306)
Protein Summary
HMGN3 is a 100-amino acid protein (UniProt Q15651) that belongs to the HMGN family. It contains a nucleosomal binding domain that mediates interaction with nucleosomes, facilitating chromatin decondensation and transcriptional activation. The protein is ubiquitously expressed and plays a role in development and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HMGN3 Knockout HEK293 Cell Line | EDJ-KQ50862 | Human | 9324 | Details Get a Quote |
| HMGN3 Knockout HeLa Cell Line | EDJ-KQ55128 | Human | 9324 | Details Get a Quote |
| HMGN3 Knockout A-549 Cell Line | EDJ-KQ63608 | Human | 9324 | Details Get a Quote |
| HMGN3 Knockout HCT 116 Cell Line | EDJ-KQ72072 | Human | 9324 | Details Get a Quote |
