HIC1: Hypermethylated in Cancer 1
A tumor suppressor gene frequently silenced by promoter hypermethylation in various cancers.
Gene Information Card
| Symbol | HIC1 |
|---|---|
| Full Name | Hypermethylated in Cancer 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 17p13.3 |
| NCBI Gene ID | 3090 ncbi.nlm.nih.gov/gene/3090 |
| Ensembl ID | ENSG00000177374 |
| UniProt ID | Q14526 |
| OMIM ID | 603825 |
| HGNC ID | 4909 |
| Aliases | ZBTB29, ZNF901, MGC133041 |
Description
HIC1 (Hypermethylated in Cancer 1) encodes a transcriptional repressor that functions as a tumor suppressor. It is frequently silenced by promoter CpG island hypermethylation in various human cancers, including breast, colon, lung, and brain tumors. The protein contains a BTB/POZ domain and five C2H2 zinc finger motifs, and it represses transcription by recruiting histone deacetylase complexes. HIC1 plays roles in growth control, development, and response to DNA damage.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Promoter hypermethylation silences HIC1 expression, contributing to tumorigenesis. | PMID: 10655551 |
| Colorectal Cancer | HIC1 methylation is an early event in colorectal carcinogenesis. | PMID: 11719428 |
| Glioblastoma | HIC1 loss via methylation promotes tumor growth and invasion. | PMID: 15229650 |
| Lung Cancer | HIC1 hypermethylation is frequent in non-small cell lung cancer. | PMID: 15355999 |
| Prostate Cancer | HIC1 methylation correlates with aggressive disease. | PMID: 15696246 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 8.5 | Medium |
| Lung | 6.2 | Low |
| Breast | 5.1 | Low |
| Colon | 4.8 | Low |
| Prostate | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 7.3 | Embryonic kidney |
| HeLa | 4.1 | Cervical cancer |
| MCF7 | 2.5 | Breast cancer, reduced expression |
| HCT116 | 1.8 | Colorectal cancer, low due to methylation |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | Rare | Unknown functional impact |
| c.202C>T | Nonsense | Rare | Premature truncation, loss of function |
| Promoter methylation | Epigenetic | Frequent in cancers | Transcriptional silencing |
Mutation functional classification
Loss of Function (LOF)
Promoter hypermethylation and nonsense mutations lead to loss of HIC1 tumor suppressor activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Transcriptional misregulation in cancer (KEGG: hsa05202)
• p53 signaling pathway (indirect regulation)
Protein Summary
The HIC1 protein is a 714-amino acid transcriptional repressor containing an N-terminal BTB/POZ domain and five C-terminal C2H2 zinc fingers. It binds to specific DNA sequences and recruits corepressor complexes, including histone deacetylases, to silence target genes involved in cell proliferation and survival. HIC1 is frequently inactivated by promoter hypermethylation in cancer, leading to derepression of oncogenic pathways.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HIC1 Knockout HEK293 Cell Line | EDJ-KQ50346 | Human | 3090 | Details Get a Quote |
| HIC1 Knockout HeLa Cell Line | EDJ-KQ53516 | Human | 3090 | Details Get a Quote |
| HIC1 Knockout A-549 Cell Line | EDJ-KQ61984 | Human | 3090 | Details Get a Quote |
| HIC1 Knockout HCT 116 Cell Line | EDJ-KQ70467 | Human | 3090 | Details Get a Quote |
