H1-5
H1.5 Linker Histone, Cluster Member
Gene Information Card
| Symbol | H1-5 |
|---|---|
| Full Name | H1.5 linker histone, cluster member |
| Gene Type | protein-coding |
| Chromosomal Location | 6p22.2 |
| NCBI Gene ID | 3009 ncbi.nlm.nih.gov/gene/3009 |
| Ensembl ID | ENSG00000184357 |
| UniProt ID | P16401 |
| OMIM ID | 142711 |
| HGNC ID | 4719 |
| Aliases | H1.5, H1b, H1F5, HIST1H1B |
Description
H1-5 encodes a member of the histone H1 family, which functions as a linker histone involved in chromatin compaction and regulation of gene expression. H1.5 binds to the linker DNA between nucleosomes, facilitating higher-order chromatin structure and modulating transcription, replication, and repair. This gene is part of the histone cluster on chromosome 6p22.2.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered H1.5 expression affects chromatin compaction and gene expression, contributing to tumorigenesis | COSMIC; PMID: 25691885 |
| Autoimmune disorders | Dysregulation of H1.5 may influence immune gene expression | ClinVar; PMID: 29100055 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 45.2 | High |
| Spleen | 32.1 | Medium |
| Lung | 28.7 | Medium |
| Brain | 15.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 38.5 | Cervical cancer cell line |
| K562 | 42.1 | Leukemia cell line |
| HEK293 | 30.2 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | missense | 0.02% | p.Pro41Leu; potential impact on DNA binding |
| c.456G>A | synonymous | 0.01% | No amino acid change |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; rare missense variants may reduce DNA binding affinity
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • DNA binding | • chromatin binding |
| • nucleosome assembly | • chromatin organization |
| • nucleus |
Pathways
• Chromatin organization
• Packaging of telomere ends
Protein Summary
H1.5 is a 226-amino acid linker histone protein (UniProt P16401) that binds to linker DNA between nucleosomes, stabilizing higher-order chromatin structure. It contains a central globular domain and disordered N- and C-terminal tails. Post-translational modifications (e.g., phosphorylation) regulate its chromatin affinity and function in transcription and cell cycle.
Related Services
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| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| No Data | ||||
