GRAP: GRB2-Related Adaptor Protein
A comprehensive overview of the GRAP gene, its protein product, expression, and associated diseases.
Gene Information Card
| Symbol | GRAP |
|---|---|
| Full Name | GRB2-related adaptor protein |
| Gene Type | protein-coding |
| Chromosomal Location | 17p11.2 |
| NCBI Gene ID | 10750 ncbi.nlm.nih.gov/gene/10750 |
| Ensembl ID | ENSG00000108771 |
| UniProt ID | Q13572 |
| OMIM ID | 604330 |
| HGNC ID | 4562 |
| Aliases | GRB2-related adaptor protein, GRB2L, GRBLG |
Description
GRAP (GRB2-related adaptor protein) encodes a member of the GRB2 family of adaptor proteins. This protein contains an SH2 domain and two SH3 domains, and functions in signal transduction pathways by linking receptor tyrosine kinases to downstream effectors. GRAP is involved in immune cell signaling, particularly in T-cell and B-cell activation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in OMIM or ClinVar | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.9 | Medium |
| Thymus | 7.6 | Medium |
| Blood | 6.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 15.1 | Leukemia cell line |
| Jurkat | 14.8 | T-cell leukemia |
| Raji | 12.3 | B-cell lymphoma |
| HEK293 | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported in ClinVar | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No known loss-of-function mutations reported.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
No known dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005070 (GO:0005070) | • GO:0007165 (GO:0007165) |
| • GO:0005102 (GO:0005102) | • GO:0005515 (GO:0005515) |
Pathways
• Signaling by Receptor Tyrosine Kinases (Reactome: R-HSA-9006934)
• Adaptor proteins in immune signaling (Reactome: R-HSA-1280218)
Protein Summary
The GRAP protein is a 217-amino acid adaptor protein with a molecular weight of approximately 24 kDa. It contains one SH2 domain and two SH3 domains, enabling it to bind phosphotyrosine motifs and proline-rich sequences. GRAP is primarily expressed in hematopoietic tissues and plays a role in coupling receptor signaling to the Ras-MAPK pathway.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GRAP2 Knockout HEK293 Cell Line | EDJ-KQ6574 | Human | 9402 | Details Get a Quote |
| GRAPL Knockout HEK293 Cell Line | EDJ-KQ11573 | Human | 400581 | Details Get a Quote |
| GRAP Knockout HEK293 Cell Line | EDJ-KQ51005 | Human | 10750 | Details Get a Quote |
| GRAP2 Knockout HeLa Cell Line | EDJ-KQ55154 | Human | 9402 | Details Get a Quote |
| GRAP Knockout HeLa Cell Line | EDJ-KQ55478 | Human | 10750 | Details Get a Quote |
| GRAPL Knockout HeLa Cell Line | EDJ-KQ60266 | Human | 400581 | Details Get a Quote |
| GRAP2 Knockout A-549 Cell Line | EDJ-KQ63634 | Human | 9402 | Details Get a Quote |
| GRAP Knockout A-549 Cell Line | EDJ-KQ63967 | Human | 10750 | Details Get a Quote |
| GRAPL Knockout A-549 Cell Line | EDJ-KQ68728 | Human | 400581 | Details Get a Quote |
| GRAP2 Knockout HCT 116 Cell Line | EDJ-KQ72096 | Human | 9402 | Details Get a Quote |
| GRAP Knockout HCT 116 Cell Line | EDJ-KQ72420 | Human | 10750 | Details Get a Quote |
| GRAPL Knockout HCT 116 Cell Line | EDJ-KQ77096 | Human | 400581 | Details Get a Quote |
