GPRC5B
G Protein-Coupled Receptor Class C Group 5 Member B
Gene Information Card
| Symbol | GPRC5B |
|---|---|
| Full Name | G protein-coupled receptor class C group 5 member B |
| Gene Type | protein-coding |
| Chromosomal Location | 16p12.3 |
| NCBI Gene ID | 51704 ncbi.nlm.nih.gov/gene/51704 |
| Ensembl ID | ENSG00000167191 |
| UniProt ID | Q9NZH0 |
| OMIM ID | 607242 |
| HGNC ID | 13309 |
| Aliases | RAIG2, GPRC5B2 |
Description
GPRC5B (G protein-coupled receptor class C group 5 member B) is a protein-coding gene that belongs to the class C family of G protein-coupled receptors. It is an orphan receptor, meaning its endogenous ligand is not yet identified. The gene is located on chromosome 16p12.3 and is also known as RAIG2 (retinoic acid-induced gene 2). GPRC5B is involved in cellular signaling and has been implicated in various cancers and metabolic processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Overexpression may promote tumor growth via GPCR signaling | PMID: 21947068 |
| Breast cancer | Altered expression linked to poor prognosis | PMID: 25691885 |
| Type 2 diabetes | Associated with insulin resistance and beta-cell dysfunction | PMID: 27864381 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Lung | 8.7 | Low |
| Liver | 6.2 | Low |
| Pancreas | 15.1 | Medium |
| Kidney | 9.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.5 | High expression |
| A549 | 22.3 | High expression |
| MCF7 | 14.2 | Medium expression |
| HepG2 | 11.8 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | missense | 0.001% | Unknown functional effect |
| c.452G>A (p.Arg151His) | missense | 0.002% | Possible altered receptor activity |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in major databases.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • signal transduction |
| • plasma membrane | • integral component of membrane |
| • retinoic acid response |
Pathways
• GPCR signaling
• Retinoic acid signaling
Protein Summary
The GPRC5B protein is a 447-amino acid orphan receptor with seven transmembrane domains. It is localized to the plasma membrane and is involved in signal transduction. The protein is induced by retinoic acid and may play roles in cell differentiation, proliferation, and metabolism. Its exact function remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPRC5B Knockout HEK293 Cell Line | EDJ-KQ11195 | Human | 51704 | Details Get a Quote |
| GPRC5B Knockout A-549 Cell Line | EDJ-KQ39250 | Human | 51704 | Details Get a Quote |
| GPRC5B Knockout HCT 116 Cell Line | EDJ-KQ39251 | Human | 51704 | Details Get a Quote |
| GPRC5B Knockout HeLa Cell Line | EDJ-KQ39252 | Human | 51704 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
