GPRC5A
G Protein-Coupled Receptor Class C Group 5 Member A
Gene Information Card
| Symbol | GPRC5A |
|---|---|
| Full Name | G protein-coupled receptor class C group 5 member A |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.31 |
| NCBI Gene ID | 9052 ncbi.nlm.nih.gov/gene/9052 |
| Ensembl ID | ENSG00000111291 |
| UniProt ID | Q8NFJ5 |
| OMIM ID | 604253 |
| HGNC ID | 9836 |
| Aliases | RAIG1, RAIG-1, RAI3, GPCR5A |
Description
GPRC5A (G protein-coupled receptor class C group 5 member A) is a protein-coding gene located on chromosome 12p13.31. It encodes a member of the class C family of G protein-coupled receptors, which is induced by retinoic acid. The protein is involved in cell growth regulation and has been implicated as a tumor suppressor in lung cancer. Expression is predominantly in lung tissue, and loss of GPRC5A expression is associated with lung carcinogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Loss of GPRC5A expression promotes tumorigenesis; acts as a tumor suppressor | PMID: 15899810, PMID: 22956720 |
| Non-small cell lung carcinoma | Downregulation of GPRC5A correlates with poor prognosis | PMID: 22956720 |
| Breast cancer | Altered expression observed; potential role in tumor progression | PMID: 19177216 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 15.2 | Medium |
| Trachea | 8.7 | Low |
| Thyroid | 3.1 | Low |
| Testis | 2.5 | Low |
| Breast | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 12.3 | High expression |
| NCI-H460 (large cell lung cancer) | 9.8 | Moderate expression |
| MCF7 (breast cancer) | 2.1 | Low expression |
| HEK293 (embryonic kidney) | 0.5 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.1% | Loss of start codon; likely loss of function |
| c.100C>T (p.Arg34Trp) | missense | <0.1% | Unknown significance |
| c.200G>A (p.Arg67Gln) | missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Loss of GPRC5A expression or function is associated with increased lung cancer risk and tumor progression.
Gain of Function (GOF)
No documented gain-of-function mutations in GPRC5A.
Dominant Negative (DN)
No documented dominant-negative mutations in GPRC5A.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • retinoic acid binding (GO:0042974) |
| • plasma membrane (GO:0005886) | • signal transduction (GO:0007165) |
| • negative regulation of cell proliferation (GO:0008285) |
Pathways
• Retinoic acid signaling pathway
• GPCR signaling pathway
Protein Summary
GPRC5A is a 357-amino acid protein belonging to the class C family of G protein-coupled receptors. It contains a seven-transmembrane domain and is localized to the plasma membrane. The protein is induced by retinoic acid and functions as a tumor suppressor, particularly in lung tissue. It negatively regulates cell proliferation and is involved in signal transduction. Loss of GPRC5A expression is a frequent event in lung cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPRC5A Knockout HEK293 Cell Line | EDJ-KQ3130 | Human | 9052 | Details Get a Quote |
| GPRC5A Knockout A-549 Cell Line | EDJ-KQ24497 | Human | 9052 | Details Get a Quote |
| GPRC5A Knockout HCT 116 Cell Line | EDJ-KQ24498 | Human | 9052 | Details Get a Quote |
| GPRC5A Knockout HeLa Cell Line | EDJ-KQ24499 | Human | 9052 | Details Get a Quote |
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