GPR61: G Protein-Coupled Receptor 61
An Orphan GPCR Involved in Metabolic Regulation and Central Nervous System Function
Gene Information Card
| Symbol | GPR61 |
|---|---|
| Full Name | G protein-coupled receptor 61 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p13.3 |
| NCBI Gene ID | 1187 ncbi.nlm.nih.gov/gene/1187 |
| Ensembl ID | ENSG00000156097 |
| UniProt ID | Q9BZJ8 |
| OMIM ID | 606926 |
| HGNC ID | 4526 |
| Aliases | GPCR3, BALGR, MGC138234 |
Description
GPR61 is an orphan G protein-coupled receptor (GPCR) that is predominantly expressed in the brain and is implicated in the regulation of energy homeostasis, feeding behavior, and body weight. It is structurally related to biogenic amine receptors but lacks a known endogenous ligand. GPR61 has been associated with obesity, metabolic syndrome, and psychiatric disorders through genetic studies and functional analyses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | GPR61 variants may alter receptor signaling affecting appetite and energy expenditure | PMID: 23583979 |
| Bipolar disorder | Genetic association studies link GPR61 polymorphisms to mood regulation | PMID: 20468064 |
| Schizophrenia | Expression changes in brain regions suggest involvement in neuropsychiatric pathways | PMID: 21743477 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebral cortex) | 12.5 | Medium |
| Brain (cerebellum) | 8.3 | Low |
| Testis | 3.1 | Low |
| Adipose tissue | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 6.8 | Neuronal model |
| HEK293 (embryonic kidney) | 0.5 | Low expression |
| U-87 MG (glioblastoma) | 4.2 | Glial cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Reduced cell surface expression |
| c.452G>A (p.Arg151His) | Missense | 0.02% | Altered cAMP signaling |
| c.784A>G (p.Ile262Val) | Missense | 0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
p.Thr34Met reduces membrane localization and receptor activity.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
Not described for GPR61.
View complete mutation data：
Gene Ontology (GO)
Pathways
• GPCR downstream signaling (cAMP pathway)
• Neuroactive ligand-receptor interaction (KEGG: hsa04080)
Protein Summary
GPR61 is a 440-amino acid orphan GPCR with seven transmembrane domains. It is highly conserved in mammals and signals primarily through Gs proteins to increase intracellular cAMP levels. The receptor is constitutively active in heterologous systems and is regulated by post-translational modifications including N-glycosylation. Its expression in hypothalamic nuclei suggests a role in central control of metabolism.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR61 Knockout HEK293 Cell Line | EDJ-KQ9109 | Human | 83873 | Details Get a Quote |
| GPR61 Knockout HeLa Cell Line | EDJ-KQ57488 | Human | 83873 | Details Get a Quote |
| GPR61 Knockout A-549 Cell Line | EDJ-KQ65992 | Human | 83873 | Details Get a Quote |
| GPR61 Knockout HCT 116 Cell Line | EDJ-KQ74415 | Human | 83873 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
