GPR37L1
G Protein-Coupled Receptor 37 Like 1
Gene Information Card
| Symbol | GPR37L1 |
|---|---|
| Full Name | G protein-coupled receptor 37 like 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q32.1 |
| NCBI Gene ID | 9283 ncbi.nlm.nih.gov/gene/9283 |
| Ensembl ID | ENSG00000170075 |
| UniProt ID | O60894 |
| OMIM ID | 602668 |
| HGNC ID | 4485 |
| Aliases | ETBR-LP-2, GPR37L1, GPR37-like 1 |
Description
GPR37L1 is an orphan G protein-coupled receptor (GPCR) closely related to GPR37. It is predominantly expressed in the brain, particularly in astrocytes and Bergmann glia. The receptor is involved in neuroprotection, regulation of cerebellar development, and modulation of dopamine signaling. Its endogenous ligand remains unidentified, but it is known to couple to Gαi/o proteins, inhibiting cAMP production.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Spinocerebellar ataxia (potential modifier) | Altered receptor expression may affect Purkinje cell survival | Animal model studies (mouse knockout) show cerebellar deficits |
| Parkinson's disease (potential modifier) | Modulation of dopamine receptor signaling | Expression changes observed in postmortem brain tissue |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebellum) | 12.5 | High |
| Brain (cortex) | 8.3 | Medium |
| Brain (hippocampus) | 7.1 | Medium |
| Testis | 2.0 | Low |
| Heart | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Astrocytes (primary) | 15.0 | High expression |
| SH-SY5Y | 3.2 | Moderate |
| HEK293 | 0.8 | Low |
| U-87 MG | 1.5 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown functional effect |
| c.457G>A (p.Val153Ile) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • G alpha-i signaling pathway (GO:0007188) |
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (GO:0007193) |
Pathways
• Class A/1 (Rhodopsin-like) GPCRs
• G alpha-i signaling events
Protein Summary
GPR37L1 is a 613-amino acid orphan GPCR with seven transmembrane domains. It shares high sequence homology with GPR37 and the endothelin B receptor. The protein is expressed on the cell surface and in intracellular compartments. It constitutively internalizes and can form heterodimers with GPR37. Its signaling is primarily through Gαi/o, leading to inhibition of adenylyl cyclase. In the brain, it is essential for proper cerebellar development and astrocyte-mediated neuroprotection.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR37L1 Knockout HEK293 Cell Line | EDJ-KQ6536 | Human | 9283 | Details Get a Quote |
| GPR37L1 Knockout HeLa Cell Line | EDJ-KQ55119 | Human | 9283 | Details Get a Quote |
| GPR37L1 Knockout A-549 Cell Line | EDJ-KQ63598 | Human | 9283 | Details Get a Quote |
| GPR37L1 Knockout HCT 116 Cell Line | EDJ-KQ72063 | Human | 9283 | Details Get a Quote |
