GPR34: G Protein-Coupled Receptor 34
A lysophosphatidylserine receptor with roles in immune regulation and cancer
Gene Information Card
| Symbol | GPR34 |
|---|---|
| Full Name | G protein-coupled receptor 34 |
| Gene Type | protein-coding |
| Chromosomal Location | Xp11.4 |
| NCBI Gene ID | 2857 ncbi.nlm.nih.gov/gene/2857 |
| Ensembl ID | ENSG00000171617 |
| UniProt ID | Q9UPC5 |
| OMIM ID | 300241 |
| HGNC ID | 4496 |
| Aliases | GPCR34, MGC138290 |
Description
GPR34 is a G protein-coupled receptor that functions as a receptor for lysophosphatidylserine (LysoPS). It is involved in immune cell regulation, mast cell activation, and phagocytosis. The gene is located on the X chromosome and is expressed in various tissues, with highest levels in immune cells. GPR34 has been implicated in several cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | GPR34 mutations and overexpression may alter LysoPS signaling, promoting tumor growth and immune evasion | COSMIC, ClinVar |
| Inflammatory bowel disease | Dysregulated GPR34 signaling in immune cells may contribute to chronic inflammation | NCBI Gene, OMIM |
| Mast cell disorders | GPR34 activation by LysoPS modulates mast cell degranulation and cytokine release | UniProt, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lung | 8.3 | Low |
| Small intestine | 7.1 | Low |
| Whole blood | 6.8 | Low |
| Bone marrow | 5.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.2 | High expression |
| Jurkat (T-cell) | 10.1 | Moderate expression |
| HEK293 | 2.3 | Low expression |
| HeLa | 1.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100G>A (p.Gly34Arg) | Missense | 0.01% | Unknown functional effect |
| c.200C>T (p.Pro67Leu) | Missense | 0.005% | Reported in COSMIC for colorectal cancer |
| c.350A>G (p.Asn117Ser) | Missense | 0.02% | Associated with altered receptor activity |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Some missense variants (e.g., p.Asn117Ser) may enhance LysoPS signaling, but evidence is limited.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • lysophosphatidylserine receptor activity |
| • signal transduction | • immune response |
| • mast cell activation |
Pathways
• Lysophosphatidylserine signaling via GPR34
• GPCR downstream signaling (cAMP
• Ca2+)
Protein Summary
GPR34 is a 7-transmembrane G protein-coupled receptor that specifically binds lysophosphatidylserine (LysoPS). Upon activation, it couples to Gαi/o proteins, leading to inhibition of cAMP production and modulation of calcium signaling. The receptor is expressed predominantly in immune cells and plays a role in regulating phagocytosis, mast cell degranulation, and cytokine release. Altered GPR34 expression and mutations have been linked to cancer and inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR34 Knockout HEK293 Cell Line | EDJ-KQ4775 | Human | 2857 | Details Get a Quote |
| GPR34 Knockout HeLa Cell Line | EDJ-KQ53408 | Human | 2857 | Details Get a Quote |
| GPR34 Knockout A-549 Cell Line | EDJ-KQ61885 | Human | 2857 | Details Get a Quote |
| GPR34 Knockout HCT 116 Cell Line | EDJ-KQ70365 | Human | 2857 | Details Get a Quote |
