GPR151: G Protein-Coupled Receptor 151
Orphan GPCR with potential roles in pain modulation and neurobiology
Gene Information Card
| Symbol | GPR151 |
|---|---|
| Full Name | G protein-coupled receptor 151 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q31.1 |
| NCBI Gene ID | 134391 ncbi.nlm.nih.gov/gene/134391 |
| Ensembl ID | ENSG00000164172 |
| UniProt ID | Q8TDV0 |
| OMIM ID | 616568 |
| HGNC ID | 23696 |
| Aliases | GALR4, GALR-like, PGR7 |
Description
GPR151 is an orphan G protein-coupled receptor (GPCR) predominantly expressed in the central nervous system, particularly in the habenula and dorsal root ganglia. It is implicated in pain signaling, neuroinflammation, and reward pathways. The receptor shows high sequence similarity to galanin receptors but does not bind galanin. GPR151 is considered a potential drug target for chronic pain and addiction disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic pain | Modulation of nociceptive signaling via GPCR pathways | PMID: 25619932 |
| Substance use disorder | Expression in habenula linked to reward and withdrawal | PMID: 28753424 |
| Neuropathic pain | Upregulation in dorsal root ganglia after nerve injury | PMID: 30321568 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cortex) | 0.4 | Low |
| Spinal cord | 1.2 | Medium |
| Dorsal root ganglia | 2.8 | High |
| Testis | 0.1 | Not detected |
| Liver | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 0.3 | Low expression |
| U-87 MG (glioblastoma) | 0.1 | Not detected |
| HEK293 (embryonic kidney) | 0.0 | Not detected |
| Primary rat DRG neurons | 3.5 | High (ortholog) |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown functional impact |
| c.482G>A (p.Arg161Gln) | Missense | <0.01% | Predicted benign |
| c.724_726del (p.Phe242del) | In-frame deletion | <0.01% | Loss of helix stability |
Mutation functional classification
Loss of Function (LOF)
c.724_726del (p.Phe242del) likely disrupts transmembrane helix packing, reducing receptor expression or signaling.
Gain of Function (GOF)
No gain-of-function variants reported in ClinVar or COSMIC.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • plasma membrane (GO:0005886) |
| • signal transduction (GO:0007165) | • neuropeptide signaling pathway (GO:0007218) |
Pathways
• G alpha (i) signaling events
• Class A/1 (Rhodopsin-like) GPCRs
Protein Summary
GPR151 is a 367-amino acid orphan GPCR with seven transmembrane domains. It is most closely related to the galanin receptor family but does not bind galanin. The receptor is highly conserved in vertebrates and is enriched in the habenula and dorsal root ganglia. Its endogenous ligand remains unknown, but it couples to Gi/o proteins, inhibiting cAMP production. GPR151 is a target of interest for pain and addiction therapeutics.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPR151 Knockout HEK293 Cell Line | EDJ-KQ9339 | Human | 134391 | Details Get a Quote |
| GPR151 Knockout HeLa Cell Line | EDJ-KQ58339 | Human | 134391 | Details Get a Quote |
| GPR151 Knockout A-549 Cell Line | EDJ-KQ66828 | Human | 134391 | Details Get a Quote |
| GPR151 Knockout HCT 116 Cell Line | EDJ-KQ75231 | Human | 134391 | Details Get a Quote |
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