GNG7 Gene: Function, Expression, and Role in Disease | G Protein Subunit Gamma 7

GNG7 encodes the gamma 7 subunit of heterotrimeric G proteins, which are critical mediators of signal transduction from G protein-coupled receptors (GPCRs). The gamma subunit, together with beta subunits, forms a beta-gamma complex that modulates downstream effectors such as adenylyl cyclases, phospholipases, and ion channels. GNG7 is widely expressed and has been implicated in various cellular processes including cell proliferation, differentiation, and apoptosis. Altered expression or mutations in GNG7 are associated with several cancers and neurological conditions.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• GPCR signaling (Reactome: R-HSA-372790)

• G beta:gamma signaling (Reactome: R-HSA-397014)

• cAMP signaling pathway (KEGG: hsa04024)

GNG7 is a 71-amino acid protein (UniProt O60262) that belongs to the G protein gamma subunit family. It forms a stable dimer with G protein beta subunits, which is essential for GPCR-mediated signal transduction. The protein is localized to the plasma membrane and interacts with various effectors. Structural studies indicate that the C-terminal domain is critical for receptor coupling and effector activation. GNG7 is highly conserved across species, underscoring its fundamental role in cellular signaling.