GMIP Gene - GEM Interacting Protein
Comprehensive gene information for GMIP, including function, expression, and disease associations.
Gene Information Card
| Symbol | GMIP |
|---|---|
| Full Name | GEM Interacting Protein |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.11 |
| NCBI Gene ID | 51291 ncbi.nlm.nih.gov/gene/51291 |
| Ensembl ID | ENSG00000104853 |
| UniProt ID | Q9P107 |
| OMIM ID | 609499 |
| HGNC ID | 24826 |
| Aliases | GEMIN7, GEM-interacting protein |
Description
GMIP (GEM Interacting Protein) encodes a protein that interacts with the Ras-like small GTPase GEM, playing a role in cytoskeletal reorganization and signal transduction. The gene is located on chromosome 19p13.11 and is expressed in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | N/A | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 8.5 | Medium |
| Heart | 6.2 | Medium |
| Liver | 4.1 | Low |
| Kidney | 5.8 | Medium |
| Lung | 7.3 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.2 | High expression |
| HeLa | 7.8 | Medium expression |
| K562 | 5.4 | Low expression |
| A549 | 6.9 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | missense | <0.01% | Unknown |
| c.456G>A | synonymous | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activator activity | • protein binding |
| • cytosol | • cytoplasm |
Pathways
• Rho GTPase signaling
• Cytoskeletal regulation
Protein Summary
The GMIP protein is a 396-amino acid protein that acts as a GTPase-activating protein (GAP) for the GEM GTPase, modulating cytoskeletal dynamics and cell morphology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GMIP Knockout HEK293 Cell Line | EDJ-KQ11017 | Human | 51291 | Details Get a Quote |
| GMIP Knockout HCT 116 Cell Line | EDJ-KQ37599 | Human | 51291 | Details Get a Quote |
| GMIP Knockout A-549 Cell Line | EDJ-KQ38900 | Human | 51291 | Details Get a Quote |
| GMIP Knockout HeLa Cell Line | EDJ-KQ38902 | Human | 51291 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
