FSCN1 (Fascin Actin-Bundling Protein 1)
Actin cross-linking protein involved in cell motility, migration, and cancer metastasis
Gene Information Card
| Symbol | FSCN1 |
|---|---|
| Full Name | Fascin Actin-Bundling Protein 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 7p22.1 |
| NCBI Gene ID | 6624 ncbi.nlm.nih.gov/gene/6624 |
| Ensembl ID | ENSG00000075618 |
| UniProt ID | Q16658 |
| OMIM ID | 602689 |
| HGNC ID | 3968 |
| Aliases | FAN1, HSN, SNL, p55 |
Description
FSCN1 encodes fascin, an actin-bundling protein that organizes filamentous actin into parallel bundles. It is essential for the formation of cellular protrusions such as filopodia and lamellipodia, playing a key role in cell adhesion, migration, and invasion. Overexpression of FSCN1 is frequently observed in various cancers and is associated with poor prognosis and metastatic potential.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast carcinoma | Overexpression of FSCN1 promotes filopodia formation and invasive migration | PMID: 15604223 |
| Colorectal carcinoma | FSCN1 upregulation correlates with lymph node metastasis and reduced survival | PMID: 17334990 |
| Pancreatic ductal adenocarcinoma | FSCN1 expression enhances cell motility and invasion via actin bundling | PMID: 21558395 |
| Esophageal squamous cell carcinoma | FSCN1 overexpression associated with tumor progression and poor outcome | PMID: 16980322 |
| Ovarian carcinoma | FSCN1 promotes metastatic dissemination through actin cytoskeleton remodeling | PMID: 19137010 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Breast | 8.1 | Medium |
| Colon | 12.4 | Medium |
| Lung | 6.7 | Low |
| Pancreas | 4.3 | Low |
| Prostate | 9.8 | Medium |
| Skin | 15.6 | High |
| Stomach | 11.2 | Medium |
| Thyroid | 7.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 18.3 | High expression; associated with invasive phenotype |
| HT-29 (colorectal cancer) | 22.1 | High expression; correlates with metastatic potential |
| PANC-1 (pancreatic cancer) | 25.6 | Very high expression; promotes migration |
| A549 (lung cancer) | 14.7 | Moderate expression |
| HeLa (cervical cancer) | 20.4 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.104C>T (p.Pro35Leu) | Missense | <0.1% | Rare; functional impact unknown |
| c.457G>A (p.Glu153Lys) | Missense | <0.1% | Rare; possibly benign |
| c.784A>G (p.Ile262Val) | Missense | <0.1% | Rare; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in FSCN1.
Gain of Function (GOF)
Overexpression and amplification of FSCN1 are common in cancers, suggesting a gain-of-function role in promoting cell motility and invasion.
Dominant Negative (DN)
No dominant-negative mutations described for FSCN1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Actin cytoskeleton regulation (KEGG: hsa04810)
• Focal adhesion (KEGG: hsa04510)
• Signaling pathways regulating pluripotency of stem cells (KEGG: hsa04550)
Protein Summary
Fascin (FSCN1) is a 55 kDa actin-bundling protein that cross-links actin filaments into tightly packed parallel bundles. It is highly expressed in neuronal tissues, dendritic cells, and various cancers. Fascin localizes to filopodia and lamellipodia, where it stabilizes actin protrusions essential for cell migration and invasion. Its overexpression in epithelial cancers is a marker of aggressive disease and poor prognosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FSCN1 Knockout HEK293 Cell Line | EDJ-KQ50643 | Human | 6624 | Details Get a Quote |
| FSCN1 Knockout HeLa Cell Line | EDJ-KQ54532 | Human | 6624 | Details Get a Quote |
| FSCN1 Knockout A-549 Cell Line | EDJ-KQ63016 | Human | 6624 | Details Get a Quote |
| FSCN1 Knockout HCT 116 Cell Line | EDJ-KQ71491 | Human | 6624 | Details Get a Quote |
