FOXL2NB
FOXL2 Neighbor: A Gene with Potential Roles in Development and Disease
Gene Information Card
| Symbol | FOXL2NB |
|---|---|
| Full Name | FOXL2 neighbor |
| Gene Type | protein-coding |
| Chromosomal Location | 3q22.3 |
| NCBI Gene ID | 100128731 ncbi.nlm.nih.gov/gene/100128731 |
| Ensembl ID | ENSG00000188690 |
| UniProt ID | Q8N6F1 |
| OMIM ID | 614356 |
| HGNC ID | 33792 |
| Aliases | FOXL2 neighbor, MGC16384 |
Description
FOXL2NB (FOXL2 neighbor) is a protein-coding gene located on chromosome 3q22.3. It is named for its proximity to the FOXL2 gene, which is involved in ovarian development and function. FOXL2NB is expressed in various tissues and may play a role in cellular processes, though its exact function is not fully characterized. Alterations in FOXL2NB have been reported in some cancers, suggesting a potential role in tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Ovarian cancer | FOXL2NB expression changes may contribute to tumorigenesis; co-amplification with FOXL2 observed | Limited evidence from cancer genomics studies |
| Breast cancer | Altered FOXL2NB expression reported in some breast cancer subtypes | Limited evidence from expression profiling |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Ovary | 5.2 | Low |
| Testis | 3.8 | Low |
| Breast | 2.1 | Low |
| Lung | 1.5 | Not detected |
| Brain | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 4.5 | Cervical cancer cell line |
| MCF7 | 3.2 | Breast cancer cell line |
| A549 | 1.1 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | missense | Rare | Unknown functional impact |
| c.456G>A | synonymous | Rare | Likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in FOXL2NB.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in FOXL2NB.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • molecular_function: protein binding (GO:0005515) | • biological_process: cellular process (GO:0009987) |
| • cellular_component: cytoplasm (GO:0005737) |
Protein Summary
The FOXL2NB protein is encoded by the FOXL2NB gene and is predicted to be localized in the cytoplasm. Its molecular function includes protein binding, suggesting involvement in protein-protein interactions. The protein's exact biological role remains under investigation, but it may participate in cellular signaling or structural processes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FOXL2NB Knockout HEK293 Cell Line | EDJ-KQ11616 | Human | 401089 | Details Get a Quote |
| FOXL2NB Knockout A-549 Cell Line | EDJ-KQ39959 | Human | 401089 | Details Get a Quote |
| FOXL2NB Knockout HeLa Cell Line | EDJ-KQ39960 | Human | 401089 | Details Get a Quote |
| FOXL2NB Knockout HCT 116 Cell Line | EDJ-KQ77117 | Human | 401089 | Details Get a Quote |
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