FNDC8
Fibronectin Type III Domain Containing 8
Gene Information Card
| Symbol | FNDC8 |
|---|---|
| Full Name | Fibronectin Type III Domain Containing 8 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q25.3 |
| NCBI Gene ID | 154865 ncbi.nlm.nih.gov/gene/154865 |
| Ensembl ID | ENSG00000187601 |
| UniProt ID | Q8N9N8 |
| OMIM ID | 617058 |
| HGNC ID | HGNC:28461 |
| Aliases | FLJ32786, MGC15619 |
Description
FNDC8 (Fibronectin Type III Domain Containing 8) is a protein-coding gene located on chromosome 17q25.3. The encoded protein contains fibronectin type III domains, which are typically involved in cell adhesion and extracellular matrix interactions. The precise biological function of FNDC8 remains under investigation, but it is expressed in various tissues and may play a role in cellular signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.0 | Moderate expression |
| HeLa | 8.5 | Low expression |
| K562 | 5.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • extracellular region | • fibronectin type III domain |
| • protein binding |
Pathways
• No curated pathways
Protein Summary
The FNDC8 protein contains fibronectin type III repeats, suggesting involvement in extracellular matrix interactions. Its exact function is not fully characterized, but it may contribute to cell adhesion or signaling processes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FNDC8 Knockout HEK293 Cell Line | EDJ-KQ51388 | Human | 54752 | Details Get a Quote |
| FNDC8 Knockout HeLa Cell Line | EDJ-KQ56465 | Human | 54752 | Details Get a Quote |
| FNDC8 Knockout A-549 Cell Line | EDJ-KQ64958 | Human | 54752 | Details Get a Quote |
| FNDC8 Knockout HCT 116 Cell Line | EDJ-KQ73402 | Human | 54752 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
