FNDC11 Gene: Function, Location, and Disease Associations | Biomedical Resource

FNDC11 (fibronectin type III domain containing 11) is a protein-coding gene located on the short arm of chromosome 1 (1p36.33). It encodes a protein that contains fibronectin type III domains, which are commonly involved in cell adhesion, migration, and signaling. The gene is expressed in various tissues, with notable levels in the testis and brain. While its exact biological function is not fully characterized, its domain architecture suggests roles in extracellular matrix interactions or receptor signaling. FNDC11 has been implicated in certain cancers and developmental processes, but further research is needed to establish definitive disease associations.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No curated pathways available; predicted involvement in integrin signaling and extracellular matrix organization.

The FNDC11 protein is predicted to be a secreted or membrane-associated protein containing fibronectin type III domains. These domains are known to mediate protein-protein interactions, particularly in cell adhesion molecules like fibronectin and cytokine receptors. The protein may play a role in cell-cell or cell-matrix interactions, influencing tissue development and homeostasis. Its expression in testis and brain suggests potential functions in spermatogenesis and neural development. However, experimental validation is lacking, and the protein's exact localization and binding partners remain to be identified.