FNDC10 (Fibronectin Type III Domain Containing 10)
A poorly characterized gene encoding a fibronectin type III domain-containing protein, with potential roles in cell adhesion and signaling.
Gene Information Card
| Symbol | FNDC10 |
|---|---|
| Full Name | Fibronectin type III domain containing 10 |
| Gene Type | protein coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000284823 |
| UniProt ID | A0A1B0GTV6 |
| OMIM ID | Not available |
| HGNC ID | 53819 |
| Aliases | None |
Description
FNDC10 is a protein-coding gene located on the short arm of chromosome 1 (1p36.33). It encodes a protein that contains fibronectin type III domains, which are commonly involved in cell adhesion, migration, and signaling. The gene is poorly characterized, and its full functional significance remains under investigation. Expression data suggest low to moderate levels in certain tissues, but detailed studies are limited.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No curated disease links in OMIM or ClinVar as of current data. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 3.2 | Low |
| Kidney | 1.5 | Low |
| Liver | 0.8 | Not detected |
| Brain | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 2.1 | Low expression |
| HeLa | 1.0 | Low expression |
| A549 | 0.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not applicable | Not available | No functional effect reported |
Mutation functional classification
Loss of Function (LOF)
No data available.
Gain of Function (GOF)
No data available.
Dominant Negative (DN)
No data available.
View complete mutation data：
Gene Ontology (GO)
| • Molecular function: Not annotated | • Biological process: Not annotated |
| • Cellular component: Not annotated |
Protein Summary
The FNDC10 protein is predicted to contain fibronectin type III domains, which are structural motifs found in many extracellular and transmembrane proteins. These domains often mediate protein-protein interactions, particularly in cell adhesion and receptor signaling. However, the specific function of FNDC10 remains unknown, and no experimental characterization has been published to date.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FNDC10 Knockout HEK293 Cell Line | EDJ-KQ13501 | Human | 643988 | Details Get a Quote |
| FNDC10 Knockout A-549 Cell Line | EDJ-KQ43114 | Human | 643988 | Details Get a Quote |
| FNDC10 Knockout HCT 116 Cell Line | EDJ-KQ43115 | Human | 643988 | Details Get a Quote |
| FNDC10 Knockout HeLa Cell Line | EDJ-KQ43116 | Human | 643988 | Details Get a Quote |
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