FNDC1
Fibronectin Type III Domain Containing 1
Gene Information Card
| Symbol | FNDC1 |
|---|---|
| Full Name | Fibronectin Type III Domain Containing 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 6q25.3 |
| NCBI Gene ID | 84624 ncbi.nlm.nih.gov/gene/84624 |
| Ensembl ID | ENSG00000164619 |
| UniProt ID | Q8TC44 |
| OMIM ID | 617632 |
| HGNC ID | 23369 |
| Aliases | KIAA1869, FLJ10769 |
Description
FNDC1 (fibronectin type III domain containing 1) is a protein-coding gene located on chromosome 6q25.3. The encoded protein contains multiple fibronectin type III domains and is involved in cell adhesion and extracellular matrix interactions. FNDC1 expression is enriched in the brain and testis, and alterations have been implicated in cancer and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression may promote tumor growth and metastasis via ECM remodeling | COSMIC; PubMed studies |
| Neurodevelopmental disorders | Potential role in neuronal migration and adhesion | ClinVar; limited evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 10.2 | Medium |
| Lung | 4.8 | Low |
| Heart | 3.1 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.7 | Moderate expression |
| SH-SY5Y | 11.3 | Neuronal cell line |
| A549 | 5.2 | Lung cancer cell line |
| MCF7 | 2.4 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.01% | Loss of function |
| c.567G>A (p.Trp189*) | Nonsense | <0.01% | Loss of function |
| c.890A>G (p.Asn297Ser) | Missense | 0.02% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg412*, p.Trp189*) are predicted to cause loss of function via premature termination.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion (GO:0007155) | • extracellular matrix organization (GO:0030198) |
| • fibronectin binding (GO:0001968) |
Pathways
• ECM-receptor interaction (KEGG hsa04512)
• Focal adhesion (KEGG hsa04510)
Protein Summary
The FNDC1 protein contains multiple fibronectin type III domains and is predicted to be a secreted or membrane-associated protein involved in cell adhesion and extracellular matrix interactions. It is expressed in brain and testis, and its dysregulation has been linked to cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FNDC1 Knockout HEK293 Cell Line | EDJ-KQ10133 | Human | 84624 | Details Get a Quote |
| FNDC11 Knockout HEK293 Cell Line | EDJ-KQ12752 | Human | 79025 | Details Get a Quote |
| FNDC10 Knockout HEK293 Cell Line | EDJ-KQ13501 | Human | 643988 | Details Get a Quote |
| FNDC10 Knockout A-549 Cell Line | EDJ-KQ43114 | Human | 643988 | Details Get a Quote |
| FNDC10 Knockout HCT 116 Cell Line | EDJ-KQ43115 | Human | 643988 | Details Get a Quote |
| FNDC10 Knockout HeLa Cell Line | EDJ-KQ43116 | Human | 643988 | Details Get a Quote |
| FNDC11 Knockout HCT 116 Cell Line | EDJ-KQ43117 | Human | 79025 | Details Get a Quote |
| FNDC11 Knockout HeLa Cell Line | EDJ-KQ57134 | Human | 79025 | Details Get a Quote |
| FNDC1 Knockout HeLa Cell Line | EDJ-KQ57620 | Human | 84624 | Details Get a Quote |
| FNDC11 Knockout A-549 Cell Line | EDJ-KQ65647 | Human | 79025 | Details Get a Quote |
| FNDC1 Knockout A-549 Cell Line | EDJ-KQ66118 | Human | 84624 | Details Get a Quote |
| FNDC1 Knockout HCT 116 Cell Line | EDJ-KQ74542 | Human | 84624 | Details Get a Quote |
Displaying Records 1 To 12 Of 12 Records
