FGF7 Gene - Fibroblast Growth Factor 7
Key regulator of epithelial cell growth and wound healing
Gene Information Card
| Symbol | FGF7 |
|---|---|
| Full Name | Fibroblast Growth Factor 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q21.1 |
| NCBI Gene ID | 2252 ncbi.nlm.nih.gov/gene/2252 |
| Ensembl ID | ENSG00000140285 |
| UniProt ID | P21781 |
| OMIM ID | 148180 |
| HGNC ID | 3685 |
| Aliases | KGF, HBGF-7 |
Description
FGF7 (fibroblast growth factor 7), also known as keratinocyte growth factor (KGF), is a member of the fibroblast growth factor family. It is primarily expressed by mesenchymal cells and acts specifically on epithelial cells via the FGFR2b receptor. FGF7 plays a critical role in embryonic development, epithelial cell proliferation, differentiation, and wound healing. Dysregulation of FGF7 is implicated in various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (e.g., breast, prostate, lung) | Overexpression of FGF7 promotes epithelial-mesenchymal transition (EMT) and tumor growth via autocrine/paracrine signaling through FGFR2b. | Multiple studies in COSMIC and PubMed; elevated FGF7 expression correlates with poor prognosis. |
| Chronic wounds / impaired healing | Reduced FGF7 expression in diabetic ulcers leads to defective keratinocyte proliferation and delayed re-epithelialization. | Clinical evidence from wound healing studies; FGF7 treatment improves healing in animal models. |
| Inflammatory bowel disease (IBD) | Altered FGF7 levels in intestinal mucosa contribute to epithelial barrier dysfunction and inflammation. | Gene expression profiling in IBD patients shows dysregulated FGF7. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 12.5 | Medium |
| Lung | 8.3 | Low |
| Kidney | 6.1 | Low |
| Prostate | 4.7 | Low |
| Breast | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HaCaT (keratinocytes) | 15.0 | High expression; used as model for epithelial response |
| MCF7 (breast cancer) | 2.1 | Low expression; exogenous FGF7 stimulates proliferation |
| A549 (lung cancer) | 1.8 | Low endogenous expression; paracrine source from fibroblasts |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | Rare | Likely loss of function; reported in ClinVar |
| c.364C>T (p.Arg122Trp) | Missense | Unknown | Potential gain of function; observed in COSMIC for colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants (e.g., p.Met1?) that disrupt protein synthesis or secretion, leading to impaired epithelial growth.
Gain of Function (GOF)
Mutations that enhance FGF7 stability or receptor binding, promoting oncogenic signaling (e.g., p.Arg122Trp).
Dominant Negative (DN)
Not well documented for FGF7; no confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• FGF signaling pathway (KEGG: hsa04010)
• MAPK signaling pathway (KEGG: hsa04010)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• Regulation of epithelial-mesenchymal transition
Protein Summary
FGF7 is a 194-amino acid secreted protein (UniProt P21781) that belongs to the fibroblast growth factor family. It contains a conserved FGF domain and binds specifically to the FGFR2b splice variant. The protein is synthesized as a precursor with a signal peptide (residues 1-31) and is processed to the mature form (residues 32-194). FGF7 is heat-labile and heparin-binding, stabilizing its interaction with the receptor. It stimulates proliferation, migration, and differentiation of epithelial cells, playing a key role in tissue repair and development.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FGF7 Knockout HEK293 Cell Line | EDJ-KQ1195 | Human | 2252 | Details Get a Quote |
| FGF7 Knockout HeLa Cell Line | EDJ-KQ53225 | Human | 2252 | Details Get a Quote |
| FGF7 Knockout A-549 Cell Line | EDJ-KQ61703 | Human | 2252 | Details Get a Quote |
| FGF7 Knockout HCT 116 Cell Line | EDJ-KQ70191 | Human | 2252 | Details Get a Quote |
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