FGF2 (Fibroblast Growth Factor 2) Gene
Key regulator of angiogenesis, cell growth, and tissue repair
Gene Information Card
| Symbol | FGF2 |
|---|---|
| Full Name | Fibroblast growth factor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q28.1 |
| NCBI Gene ID | 2247 ncbi.nlm.nih.gov/gene/2247 |
| Ensembl ID | ENSG00000138685 |
| UniProt ID | P09038 |
| OMIM ID | 134920 |
| HGNC ID | 3676 |
| Aliases | bFGF, FGFB, HBGF-2 |
Description
FGF2 (fibroblast growth factor 2) encodes a member of the fibroblast growth factor (FGF) family. The encoded protein is a potent mitogen and angiogenic factor involved in embryonic development, cell growth, morphogenesis, tissue repair, and tumor growth. FGF2 binds to FGF receptors (FGFRs) and heparan sulfate proteoglycans to initiate signaling cascades.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Overexpression of FGF2 promotes angiogenesis and tumor growth via autocrine/paracrine signaling | COSMIC, ClinVar |
| Coronary artery disease | FGF2 polymorphisms associated with altered angiogenic response | OMIM, NCBI |
| Retinopathy of prematurity | Elevated FGF2 contributes to pathological neovascularization | ClinVar, literature |
| Skeletal dysplasias | FGF2 signaling dysregulation linked to abnormal bone growth | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Heart | 8.7 | Low |
| Lung | 15.2 | Medium |
| Liver | 6.1 | Low |
| Kidney | 10.5 | Medium |
| Placenta | 22.8 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.4 | Cervical cancer cell line |
| A549 | 14.2 | Lung cancer cell line |
| MCF7 | 9.8 | Breast cancer cell line |
| HUVEC | 25.6 | Endothelial cells, high expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Reduced protein stability |
| c.472C>T | Nonsense | <0.1% | Premature truncation, loss of function |
| c.614G>A | Missense | <0.1% | Altered receptor binding affinity |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations leading to truncated protein or reduced activity.
Gain of Function (GOF)
Missense mutations that enhance receptor binding or protein stability, observed in some cancers.
Dominant Negative (DN)
Not well documented for FGF2; most mutations are recessive or neutral.
View complete mutation data：
Gene Ontology (GO)
Pathways
• FGF signaling pathway (KEGG: hsa04010)
• MAPK signaling pathway (KEGG: hsa04010)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• Ras signaling pathway (KEGG: hsa04014)
Protein Summary
FGF2 (basic fibroblast growth factor, bFGF) is a 18-24 kDa heparin-binding growth factor. It exists in multiple isoforms due to alternative initiation of translation. The protein lacks a classical signal peptide and is secreted via an unconventional pathway. FGF2 binds to FGFR1-4 and heparan sulfate, activating downstream pathways including MAPK, PI3K/Akt, and PLCγ. It plays critical roles in angiogenesis, wound healing, and embryonic development. Dysregulation is implicated in cancer and vascular diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FGF20 Knockout HEK293 Cell Line | EDJ-KQ661 | Human | 26281 | Details Get a Quote |
| FGF23 Knockout HEK293 Cell Line | EDJ-KQ662 | Human | 8074 | Details Get a Quote |
| FGF2 Knockout HEK293 Cell Line | EDJ-KQ17695 | Human | 2247 | Details Get a Quote |
| FGF21 Knockout HEK293 Cell Line | EDJ-KQ17774 | Human | 26291 | Details Get a Quote |
| FGF2 Knockout A-549 Cell Line | EDJ-KQ19169 | Human | 2247 | Details Get a Quote |
| FGF2 Knockout HCT 116 Cell Line | EDJ-KQ19170 | Human | 2247 | Details Get a Quote |
| FGF2 Knockout HeLa Cell Line | EDJ-KQ19171 | Human | 2247 | Details Get a Quote |
| FGF23 Knockout HeLa Cell Line | EDJ-KQ18297 | Human | 8074 | Details Get a Quote |
| FGF22 Knockout HEK293 Cell Line | EDJ-KQ51196 | Human | 27006 | Details Get a Quote |
| FGF20 Knockout HeLa Cell Line | EDJ-KQ55920 | Human | 26281 | Details Get a Quote |
| FGF21 Knockout HeLa Cell Line | EDJ-KQ55926 | Human | 26291 | Details Get a Quote |
| FGF22 Knockout HeLa Cell Line | EDJ-KQ55980 | Human | 27006 | Details Get a Quote |
| FGF23 Knockout A-549 Cell Line | EDJ-KQ63309 | Human | 8074 | Details Get a Quote |
| FGF20 Knockout A-549 Cell Line | EDJ-KQ64410 | Human | 26281 | Details Get a Quote |
| FGF21 Knockout A-549 Cell Line | EDJ-KQ64414 | Human | 26291 | Details Get a Quote |
Displaying Records 1 To 15 Of 21 Records
