FGF1: Fibroblast Growth Factor 1
A key angiogenic and neurotrophic factor involved in development, repair, and cancer
Gene Information Card
| Symbol | FGF1 |
|---|---|
| Full Name | Fibroblast Growth Factor 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q31.3 |
| NCBI Gene ID | 2246 ncbi.nlm.nih.gov/gene/2246 |
| Ensembl ID | ENSG00000113578 |
| UniProt ID | P05230 |
| OMIM ID | 131220 |
| HGNC ID | 3665 |
| Aliases | AFGF, ECGF, ECGF-beta, FGF-alpha, HBGF-1 |
Description
FGF1 (Fibroblast Growth Factor 1) encodes a member of the fibroblast growth factor (FGF) family. This protein functions as a potent mitogen and angiogenic factor, binding to FGF receptors (FGFRs) to regulate cell proliferation, differentiation, migration, and survival. FGF1 is involved in embryonic development, tissue repair, and neuroprotection. Dysregulation of FGF1 signaling is implicated in various cancers, cardiovascular diseases, and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | FGF1 overexpression promotes angiogenesis and tumor growth via FGFR activation | COSMIC; PMID: 25691885 |
| Coronary artery disease | FGF1 polymorphisms associated with altered angiogenic response | ClinVar; PMID: 21824916 |
| Neurodegenerative disorders | FGF1 neurotrophic effects may protect against neuronal loss | UniProt; PMID: 23583315 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Kidney | 15.1 | Medium |
| Liver | 6.2 | Low |
| Lung | 9.8 | Low |
| Skeletal Muscle | 4.7 | Low |
| Spleen | 11.0 | Medium |
| Testis | 18.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 22.3 | High expression |
| HeLa | 14.1 | Moderate expression |
| A549 | 9.5 | Low expression |
| MCF7 | 16.8 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.160G>A (p.Glu54Lys) | Missense | Rare | Altered receptor binding affinity |
| c.367C>T (p.Arg123Trp) | Missense | Rare | Reduced protein stability |
| c.1A>G (p.Met1Val) | Start loss | Rare | Loss of translation initiation |
Mutation functional classification
Loss of Function (LOF)
Mutations that disrupt FGF1 secretion or receptor binding (e.g., p.Arg123Trp) reduce angiogenic signaling.
Gain of Function (GOF)
Overexpression or activating mutations (e.g., p.Glu54Lys) enhance FGFR signaling and promote tumorigenesis.
Dominant Negative (DN)
Truncated FGF1 variants that sequester FGFRs without activating downstream pathways.
View complete mutation data：
Gene Ontology (GO)
| • GO:0008083: growth factor activity | • GO:0005104: fibroblast growth factor receptor binding |
| • GO:0008284: positive regulation of cell population proliferation | • GO:0001525: angiogenesis |
| • GO:0043524: negative regulation of neuron apoptotic process | • GO:0005615: extracellular space |
Pathways
• MAPK signaling pathway (KEGG: hsa04010)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• Ras signaling pathway (KEGG: hsa04014)
• FGF signaling pathway (Reactome: R-HSA-190236)
Protein Summary
FGF1 (acidic FGF) is a 155-amino acid heparin-binding growth factor. It lacks a classical signal peptide and is secreted via an unconventional pathway. The protein adopts a beta-trefoil fold and binds to all four FGFRs with high affinity, requiring heparan sulfate proteoglycans as co-receptors. FGF1 is a potent inducer of angiogenesis and neuroprotection, and its recombinant form is used in therapeutic contexts for wound healing and ischemia.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FGF16 Knockout HEK293 Cell Line | EDJ-KQ167 | Human | 8823 | Details Get a Quote |
| FGF10 Knockout HEK293 Cell Line | EDJ-KQ649 | Human | 2255 | Details Get a Quote |
| FGF19 Knockout HEK293 Cell Line | EDJ-KQ660 | Human | 9965 | Details Get a Quote |
| FGF17 Knockout HEK293 Cell Line | EDJ-KQ1194 | Human | 8822 | Details Get a Quote |
| FGF18 Knockout HEK293 Cell Line | EDJ-KQ1196 | Human | 8817 | Details Get a Quote |
| FGF12 Knockout HEK293 Cell Line | EDJ-KQ2137 | Human | 2257 | Details Get a Quote |
| FGF13 Knockout HEK293 Cell Line | EDJ-KQ2293 | Human | 2258 | Details Get a Quote |
| FGF11 Knockout HEK293 Cell Line | EDJ-KQ2712 | Human | 2256 | Details Get a Quote |
| FGF14 Knockout HEK293 Cell Line | EDJ-KQ3839 | Human | 2259 | Details Get a Quote |
| FGF1 Knockout HEK293 Cell Line | EDC07556 | Human | 2246 | Details Get a Quote |
| FGF19 Knockout HCT 116 Cell Line | EDJ-KQ19168 | Human | 9965 | Details Get a Quote |
| FGF18 Knockout HCT 116 Cell Line | EDJ-KQ20497 | Human | 8817 | Details Get a Quote |
| FGF12 Knockout HeLa Cell Line | EDJ-KQ22299 | Human | 2257 | Details Get a Quote |
| FGF11 Knockout HCT 116 Cell Line | EDJ-KQ23557 | Human | 2256 | Details Get a Quote |
| FGF11 Knockout HeLa Cell Line | EDJ-KQ23558 | Human | 2256 | Details Get a Quote |
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