FETUB Gene - Fetuin B
Comprehensive genomic and proteomic overview of FETUB, a member of the fetuin family involved in calcium metabolism and inflammation.
Gene Information Card
| Symbol | FETUB |
|---|---|
| Full Name | fetuin B |
| Gene Type | protein-coding |
| Chromosomal Location | 3q27.3 |
| NCBI Gene ID | 26998 ncbi.nlm.nih.gov/gene/26998 |
| Ensembl ID | ENSG00000170820 |
| UniProt ID | Q9UGM5 |
| OMIM ID | 605954 |
| HGNC ID | 3658 |
| Aliases | Gugu, IRP, MGC119173, MGC119174, MGC119175 |
Description
FETUB (fetuin B) is a protein-coding gene located on chromosome 3q27.3. It encodes a member of the fetuin family, which are secreted glycoproteins involved in calcium metabolism, osteogenesis, and inflammatory responses. Fetuin B is primarily expressed in the liver and is known to inhibit insulin receptor tyrosine kinase activity, potentially playing a role in insulin resistance and type 2 diabetes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Metabolic syndrome | Fetuin B may modulate insulin signaling and contribute to insulin resistance | PMID: 23431276 |
| Type 2 diabetes | Altered FETUB expression linked to impaired glucose homeostasis | PMID: 25687266 |
| Osteoporosis | Fetuin B influences bone mineralization and calcium homeostasis | PMID: 20089939 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | High |
| Adipose tissue | 3.2 | Medium |
| Kidney | 1.8 | Low |
| Heart | 0.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.3 | Hepatocellular carcinoma cell line |
| Huh-7 | 11.8 | Hepatoma cell line |
| 3T3-L1 | 4.5 | Adipocyte precursor cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | p.Met1Val; potential loss of start codon |
| c.215C>T | missense | <0.01% | p.Thr72Ile; unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Insulin signaling pathway (Reactome: R-HSA-74752)
• Mineral absorption (KEGG: hsa04978)
Protein Summary
Fetuin B is a 382-amino acid secreted glycoprotein with a molecular weight of approximately 42 kDa. It contains two cystatin-like domains and is involved in the regulation of calcium metabolism, insulin signaling, and inflammation. The protein is primarily synthesized in the liver and circulates in plasma. Fetuin B inhibits insulin receptor autophosphorylation and tyrosine kinase activity, contributing to insulin resistance. It also binds to calcium and hydroxyapatite, influencing bone mineralization and ectopic calcification.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FETUB Knockout HEK293 Cell Line | EDJ-KQ7909 | Human | 26998 | Details Get a Quote |
| FETUB Knockout HeLa Cell Line | EDJ-KQ55979 | Human | 26998 | Details Get a Quote |
| FETUB Knockout A-549 Cell Line | EDJ-KQ64463 | Human | 26998 | Details Get a Quote |
| FETUB Knockout HCT 116 Cell Line | EDJ-KQ72921 | Human | 26998 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
