FES Tyrosine Kinase Gene
A proto-oncogene encoding a non-receptor tyrosine kinase involved in hematopoiesis and cell signaling
Gene Information Card
| Symbol | FES |
|---|---|
| Full Name | FES proto-oncogene, tyrosine kinase |
| Gene Type | protein-coding |
| Chromosomal Location | 15q26.1 |
| NCBI Gene ID | 2242 ncbi.nlm.nih.gov/gene/2242 |
| Ensembl ID | ENSG00000168056 |
| UniProt ID | P07332 |
| OMIM ID | 190030 |
| HGNC ID | 3658 |
| Aliases | FPS, FES/FPS |
Description
The FES gene encodes a non-receptor tyrosine kinase that belongs to the FES/FER family. It is involved in the regulation of cell growth, differentiation, and survival, particularly in hematopoietic cells. The protein contains an N-terminal FCH domain, a central SH2 domain, and a C-terminal tyrosine kinase domain. FES is implicated in myeloid leukemia and other cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute myeloid leukemia | FES overexpression or fusion proteins (e.g., FES-FGFR1) drive aberrant kinase signaling and proliferation | COSMIC, ClinVar |
| Myeloproliferative neoplasms | Activating mutations or translocations involving FES lead to constitutive kinase activity | COSMIC, OMIM |
| Colorectal cancer | FES expression is altered in some colorectal tumors, potentially affecting cell adhesion and migration | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Lung | 8.1 | Low |
| Kidney | 6.3 | Low |
| Liver | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (chronic myeloid leukemia) | 15.3 | High expression |
| HL-60 (acute promyelocytic leukemia) | 14.1 | High expression |
| HEK 293 (embryonic kidney) | 7.2 | Moderate expression |
| MCF7 (breast cancer) | 5.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Gly703Arg | Missense | <0.1% | Unknown; observed in COSMIC |
| p.Arg481Trp | Missense | <0.1% | Unknown; observed in COSMIC |
| FES-FGFR1 fusion | Translocation | Rare | Oncogenic; constitutive kinase activation |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
FES-FGFR1 fusions and certain missense mutations (e.g., p.Gly703Arg) are predicted to increase kinase activity.
Dominant Negative (DN)
Not described for FES.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine kinase activity | • ATP binding |
| • signal transduction | • cell differentiation |
| • hematopoiesis | • positive regulation of cell proliferation |
Pathways
• Signaling by Receptor Tyrosine Kinases
• Fc epsilon receptor (FCERI) signaling
• Innate Immune System
Protein Summary
The FES protein (UniProt P07332) is a 822-amino acid non-receptor tyrosine kinase. It localizes to the cytoplasm and is involved in signaling downstream of growth factor receptors and integrins. FES regulates myeloid cell differentiation and survival. Its kinase domain is essential for catalytic activity, and the SH2 domain mediates interactions with phosphotyrosine-containing proteins.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FES Knockout HEK293 Cell Line | EDJ-KQ4585 | Human | 2242 | Details Get a Quote |
| RFESD Knockout HEK293 Cell Line | EDJ-KQ8877 | Human | 317671 | Details Get a Quote |
| RFESD Knockout HCT 116 Cell Line | EDJ-KQ33967 | Human | 317671 | Details Get a Quote |
| RFESD Knockout A-549 Cell Line | EDJ-KQ35200 | Human | 317671 | Details Get a Quote |
| RFESD Knockout HeLa Cell Line | EDJ-KQ35201 | Human | 317671 | Details Get a Quote |
| FES Knockout A-549 Cell Line | EDJ-KQ27241 | Human | 2242 | Details Get a Quote |
| FES Knockout HCT 116 Cell Line | EDJ-KQ27242 | Human | 2242 | Details Get a Quote |
| FES Knockout HeLa Cell Line | EDJ-KQ53217 | Human | 2242 | Details Get a Quote |
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